Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Klaus Bonnelykke; Melanie C. Matheson; Tune H. Pers; Raquel Granell; David P. Strachan; Alexessander Couto Alves; Allan Linneberg; John A. Curtin; Nicole M. Warrington; Marie Standl; Marjan Kerkhof; Ingileif Jonsdottir; Blazenka K. Bukvic; Marika Kaakinen; Patrick Sleimann; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Katharina Schramm; Svetlana Baltic; Eskil Kreiner-Moller; Angela Simpson; Beate St Pourcain; Lachlan Coin; Jennie Hui; Eugene H. Walters; Carla M. T. Tiesler; David L. Duffy; Graham Jones; Susan M. Ring; Wendy L. McArdle; Loren Price; Colin F. Robertson; Juha Pekkanen; Clara S. Tang; Elisabeth Thiering; Grant W. Montgomery; Anna-Liisa Hartikainen; Shyamali C. Dharmage; Lise L. Husemoen; Christian Herder; John P. Kemp; Paul Elliot; Alan James; Melanie Waldenberger; Michael J. Abramson; Benjamin P. Fairfax; Julian C. Knight; Ramneek Gupta; Philip J. Thompson; Patrick Holt; Peter Sly; Joel N. Hirschhorn; Mario Blekic; Stephan Weidinger; Hakon Hakonarsson; Kari Stefansson; Joachim Heinrich; Dirkje S. Postma; Adnan Custovic; Craig E. Pennell; Marjo-Riitta Jarvelin; Gerard H. Koppelman; Nicholas Timpson; Manuel A. Ferreira; Hans Bisgaard; A. John Henderson; AAGC; Loren Flynn

doi:10.1038/ng.2694

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Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Journal article

Peer reviewed

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Klaus Bonnelykke, Melanie C. Matheson, Tune H. Pers, Raquel Granell, David P. Strachan, Alexessander Couto Alves, Allan Linneberg, John A. Curtin, Nicole M. Warrington, Marie Standl, …

Nature genetics, Vol.45(8), pp.902-906

2013

DOI: https://doi.org/10.1038/ng.2694

PMID: 23817571

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.

Details

Title: Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization
Authors/Creators: Klaus Bonnelykke - University of Copenhagen
Melanie C. Matheson - The University of Melbourne
Tune H. Pers - Tech Univ Denmark, Ctr Biol Sequence Anal, DK-2800 Lyngby, Denmark
Raquel Granell - University of Bristol
David P. Strachan - St George's, University of London
Alexessander Couto Alves - Imperial College London
Allan Linneberg - Glostrup Hospital
John A. Curtin - Univ Manchester, Univ Hosp South Manchester Natl Hlth Serv NHS Fdn, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England
Nicole M. Warrington - The University of Western Australia
Marie Standl - Helmholtz Zentrum München
Marjan Kerkhof - University Medical Center Groningen
Ingileif Jonsdottir - University of Iceland
Blazenka K. Bukvic - University of Osijek
Marika Kaakinen - University of Oulu
Patrick Sleimann - University of Pennsylvania
Gudmar Thorleifsson - deCODE Genetics (Iceland)
Unnur Thorsteinsdottir - deCODE Genetics (Iceland)
Katharina Schramm - Helmholtz Zentrum München
Svetlana Baltic - University of Washington
Eskil Kreiner-Moller - University of Copenhagen
Angela Simpson - University of Manchester
Beate St Pourcain - University of Bristol
Lachlan Coin - University of London
Jennie Hui - College Station Medical Center
Eugene H. Walters - University of Tasmania
Carla M. T. Tiesler - Helmholtz Zentrum München
David L. Duffy - QIMR Berghofer Medical Research Institute
Graham Jones - Western Sydney University
Susan M. Ring - University of Bristol
Wendy L. McArdle - University of Bristol
Loren Price - The University of Western Australia
Colin F. Robertson - Murdoch Childrens Research Institute
Juha Pekkanen - University of Eastern Finland
Clara S. Tang - QIMR Berghofer Medical Research Institute
Elisabeth Thiering - Helmholtz Zentrum München
Grant W. Montgomery - QIMR Berghofer Medical Research Institute
Anna-Liisa Hartikainen - University of Oulu
Shyamali C. Dharmage - The University of Melbourne
Lise L. Husemoen - Glostrup Hospital
Christian Herder - Heinrich Heine University Düsseldorf
John P. Kemp - University of Bristol
Paul Elliot - Imperial College London
Alan James - The University of Western Australia
Melanie Waldenberger - Helmholtz Zentrum München
Michael J. Abramson - Monash University
Benjamin P. Fairfax - Centre for Human Genetics
Julian C. Knight - University of Oxford
Ramneek Gupta - Tech Univ Denmark, Ctr Biol Sequence Anal, DK-2800 Lyngby, Denmark
Philip J. Thompson - The University of Western Australia
Patrick Holt - The Kids Research Institute Australia
Peter Sly - Children's Medical Research Institute
Joel N. Hirschhorn - Broad Institute
Mario Blekic - University of Osijek
Stephan Weidinger - Christian-Albrechts-Universität zu Kiel
Hakon Hakonarsson - University of Pennsylvania
Kari Stefansson - deCODE Genetics (Iceland)
Joachim Heinrich - Helmholtz Zentrum München
Dirkje S. Postma - University Medical Center Groningen
Adnan Custovic - University of Manchester
Craig E. Pennell - The University of Western Australia
Marjo-Riitta Jarvelin - University of Oulu
Gerard H. Koppelman - University Medical Center Groningen
Nicholas Timpson - University of Bristol
Manuel A. Ferreira - QIMR Berghofer Medical Research Institute
Hans Bisgaard - Copenhagen University Hospital
A. John Henderson - University of Bristol
AAGC
Loren Flynn - Centre for Molecular Medicine and Innovative Therapeutics
Publication Details: Nature genetics, Vol.45(8), pp.902-906
Publisher: Springer Nature
Number of pages: 7
Grant note: 092731; 090532 / Wellcome Trust; European Commission G1001799 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) G0801056B / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission CL-2012-13-004 / National Institute for Health Research; National Institute for Health Research (NIHR) R16-2007-1694 / Lundbeck Foundation; Lundbeckfonden G0801056; G1001799; G9815508; MC_UU_12013/3; MR/K002449/1; MC_PC_15018; G0601361 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission
Identifiers: 991005591573907891
Copyright: © 2013 Springer Nature Limited
Murdoch Affiliation: Centre for Molecular Medicine and Innovative Therapeutics
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.65 Allergy; 1.65.44 Asthma
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics