Metabolic profiling of a transgenic Caenorhabditis elegans Alzheimer model

R. Van Assche; L. Temmerman; D.A. Dias; B. Boughton; K. Boonen; B.P. Braeckman; L. Schoofs; U. Roessner

doi:10.1007/s11306-014-0711-5

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Metabolic profiling of a transgenic Caenorhabditis elegans Alzheimer model

Journal article

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Peer reviewed

Metabolic profiling of a transgenic Caenorhabditis elegans Alzheimer model

R. Van Assche, L. Temmerman, D.A. Dias, B. Boughton, K. Boonen, B.P. Braeckman, L. Schoofs and U. Roessner

Metabolomics, Vol.11, pp.477-486

2015

DOI: https://doi.org/10.1007/s11306-014-0711-5

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Abstract

Despite decades of research, no early-onset biomarkers are currently available for Alzheimer’s disease, a cureless neurodegenerative disease afflicting millions worldwide. In this study, transgenic Caenorhabditis elegans were used to investigate changes in the metabolome after induced expression of amyloid-β. GC- and LC–MS-based platforms determined a total of 157 differential features. Some of these were identified using in-house (GC–MS) or public libraries (LC–MS), revealing changes in allantoin, cystathionine and tyrosine levels. Since C. elegans is far better suited to metabolomics studies than most other model systems, the accordance of these findings with vertebrate literature is promising and argues for further use of C. elegans as a model of human pathology in the study of AD.

Details

Title: Metabolic profiling of a transgenic Caenorhabditis elegans Alzheimer model
Authors/Creators: R. Van Assche (Author/Creator) - KU Leuven
L. Temmerman (Author/Creator) - KU Leuven
D.A. Dias (Author/Creator) - The University of Melbourne
B. Boughton (Author/Creator) - The University of Melbourne
K. Boonen (Author/Creator) - KU Leuven
B.P. Braeckman (Author/Creator) - Ghent University
L. Schoofs (Author/Creator) - KU Leuven
U. Roessner (Author/Creator) - The University of Melbourne
Publication Details: Metabolomics, Vol.11, pp.477-486
Publisher: Springer
Identifiers: 991005543150707891
Copyright: © The Author(s) 2014
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 2 Chemistry; 2.211 Mass Spectrometry; 2.211.990 Metabolomics
Web Of Science research areas: Endocrinology & Metabolism
ESI research areas: Biology & Biochemistry