Journal article
Metabolic profiling of diabetic cats in remission
Frontiers in Veterinary Science, Vol.7, Article 218
2020
Abstract
Background: The majority of diabetic cats in remission have abnormal glucose tolerance, and approximately one third relapse within 1 year. Greater understanding of the metabolic characteristics of diabetic cats in remission, and predictors of relapse is required to effectively monitor and manage these cats.
Objectives: To identify and compare differences in plasma metabolites between diabetic cats in remission and healthy control cats using a metabolomics approach. Secondly, to assess whether identified metabolites are predictors of diabetic relapse.
Animals: Twenty cats in diabetic remission for a median of 101 days, and 22 healthy matched control cats.
Methods: Cats were admitted to a clinic, and casual blood glucose was recorded. After a 24 h fast, blood glucose concentration was measured, then a blood sample was taken for metabolomic (GCMS and LCMS) analyses. Three hours later, a simplified intravenous glucose tolerance test (1 g glucose/kg) was performed. Cats were monitored for diabetes relapse for at least 9 months (270 days) after baseline testing.
Results: Most cats in remission continued to display impaired glucose tolerance. Concentrations of 16 identified metabolites differed (P ≤ 0.05) between remission and control cats: 10 amino acids and stearic acid (all lower in remission cats), and glucose, glycine, xylitol, urea and carnitine (all higher in remission cats). Moderately close correlations were found between these 16 metabolites and variables assessing glycaemic responses (most |r| = 0.31 to 0.69). Five cats in remission relapsed during the study period. No metabolite was identified as a predictor of relapse.
Conclusion and clinical importance: This study shows that cats in diabetic remission have abnormal metabolism.
Details
- Title
- Metabolic profiling of diabetic cats in remission
- Authors/Creators
- S. Gottlieb (Author/Creator) - The University of QueenslandJ. Rand (Author/Creator) - The University of QueenslandS.T. Anderson (Author/Creator) - The University of QueenslandJ.M. Morton (Author/Creator) - The University of QueenslandD.A. Dias (Author/Creator) - RMIT UniversityB.A. Boughton (Author/Creator) - The University of MelbourneU. Roessner (Author/Creator) - The University of MelbourneZ. Ramadan (Author/Creator) - Nestlé Purina PetCare Company
- Publication Details
- Frontiers in Veterinary Science, Vol.7, Article 218
- Publisher
- Frontiers Media
- Identifiers
- 991005544893907891
- Copyright
- © 2020 The Authors
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Citation topics
- 2 Chemistry
- 2.211 Mass Spectrometry
- 2.211.990 Metabolomics
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science