Journal article
Metabolite profiling identifies the mycotoxin alternariol in the pathogen Stagonospora nodorum
Metabolomics, Vol.5(3), pp.330-335
2009
Abstract
A recent comparative proteomics study identified the short-chain dehydrogenase (Sch1) as being required for asexual sporulation (Tan et al. Eukaryotic Cell 7:1916–1929, 2008). Metabolite profiling was undertaken on the mutant strains of Stagonospora nodorum lacking the Sch1 gene to help elucidate its role. Gas chromatography-mass spectrometry of the polar metabolites in the Sch1 mutants identified a secondary metabolite at a 200-fold greater concentration than observed in the wild-type strains. Comparative analysis of the secondary metabolite and the mycotoxin alternariol using ESI-MS/MS confirmed the identity of the compound as alternariol. This is the first report to confirm the presence of a mycotoxin in S. nodorum and compelling the field to consider the health implication of this disease.
Details
- Title
- Metabolite profiling identifies the mycotoxin alternariol in the pathogen Stagonospora nodorum
- Authors/Creators
- K.C. Tan (Author/Creator)R.D. Trengove (Author/Creator)G.L. Maker (Author/Creator)R.P. Oliver (Author/Creator)P.S. Solomon (Author/Creator)
- Publication Details
- Metabolomics, Vol.5(3), pp.330-335
- Publisher
- Springer
- Identifiers
- 991005540577507891
- Copyright
- Springer
- Murdoch Affiliation
- School of Pharmacy
- Language
- English
- Resource Type
- Journal article
Metrics
172 File views/ downloads
46 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.148 Medical Mycology
- 1.148.240 Saccharomyces Cerevisiae
- Web Of Science research areas
- Endocrinology & Metabolism
- ESI research areas
- Biology & Biochemistry