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Published (Version of Record)CC BY V4.0, Open Access
Journal article
Metabolomics and lipidomics: Expanding the molecular landscape of exercise biology
Metabolites, Vol.11(3), Article 151
2021
Abstract
Dynamic changes in circulating and tissue metabolites and lipids occur in response to exercise-induced cellular and whole-body energy demands to maintain metabolic homeostasis. The metabolome and lipidome in a given biological system provides a molecular snapshot of these rapid and complex metabolic perturbations. The application of metabolomics and lipidomics to map the metabolic responses to an acute bout of aerobic/endurance or resistance exercise has dramatically expanded over the past decade thanks to major analytical advancements, with most exercise-related studies to date focused on analyzing human biofluids and tissues. Experimental and analytical considerations, as well as complementary studies using animal model systems, are warranted to help overcome challenges associated with large human interindividual variability and decipher the breadth of molecular mechanisms underlying the metabolic health-promoting effects of exercise. In this review, we provide a guide for exercise researchers regarding analytical techniques and experimental workflows commonly used in metabolomics and lipidomics. Furthermore, we discuss advancements in human and mammalian exercise research utilizing metabolomic and lipidomic approaches in the last decade, as well as highlight key technical considerations and remaining knowledge gaps to continue expanding the molecular landscape of exercise biology.
Details
- Title
- Metabolomics and lipidomics: Expanding the molecular landscape of exercise biology
- Authors/Creators
- M.R. Belhaj (Author/Creator) - Australian Catholic UniversityN.G. Lawler (Author/Creator) - Murdoch UniversityN.J. Hoffman (Author/Creator) - Australian Catholic University
- Publication Details
- Metabolites, Vol.11(3), Article 151
- Publisher
- MDPI
- Identifiers
- 991005541016007891
- Copyright
- © 2021 by the authors
- Murdoch Affiliation
- Australian National Phenome Centre; Health Futures Institute
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
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- Citation topics
- 2 Chemistry
- 2.211 Mass Spectrometry
- 2.211.990 Metabolomics
- Web Of Science research areas
- Biochemistry & Molecular Biology
- ESI research areas
- Biology & Biochemistry