Journal article
MiR-Score: A novel 6-microRNA signature that predicts survival outcomes in patients with malignant pleural mesothelioma
Molecular Oncology, Vol.9(3), pp.715-726
2015
Abstract
Background
Prognosis of malignant pleural mesothelioma (MPM) is poor, and predicting the outcomes of treatment is difficult. Here we investigate the potential of microRNA expression to estimate prognosis of MPM patients.
Methods
Candidate microRNAs from microarray profiling of tumor samples from 8 long (median: 53.7 months) and 8 short (median: 6.4 months) survivors following extrapleural pneumonectomy (EPP) were validated by RT-qPCR in 48 additional EPP samples. Kaplan–Meier log ranking was used to further explore the association between microRNA expression and overall survival (OS). Binary logistic regression was used to construct a microRNA signature (miR-Score) that was able to predict an OS of ≥20 months. Performance of the miR-Score was evaluated by receiver operating characteristic (ROC) curve analysis and validated in a series of 43 tumor samples from patients who underwent palliative surgery [pleurectomy/decortication (P/D)].
Results
The miR-Score, using expression data of six microRNAs (miR-21-5p, -23a-3p, -30e-5p, -221-3p, -222-3p, and -31-5p), enabled prediction of long survival with an accuracy of 92.3% for EPP and 71.9% for palliative P/D. Hazard ratios for score-negative patients were 4.12 (95% CI: 2.03–8.37) for EPP and 1.93 (95% CI: 1.01–3.69) for P/D. Importantly, adding the miR-Score to a set of clinical selection criteria (histology, age, gender) increased predictive accuracy in the independent validation set from 76.3% for clinical factors only to 87.3%.
Conclusions
This study has identified a novel 6-microRNA signature (miR-Score) that can accurately predict prognosis of MPM patients.
Details
- Title
- MiR-Score: A novel 6-microRNA signature that predicts survival outcomes in patients with malignant pleural mesothelioma
- Authors/Creators
- M.B. Kirschner (Author/Creator) - The University of SydneyY.Y. Cheng (Author/Creator) - Asbestos Diseases Research InstituteN.J. Armstrong (Author/Creator) - The University of SydneyR.C.Y. Lin (Author/Creator) - UNSW SydneyS.C. Kao (Author/Creator) - Asbestos Diseases Research InstituteA. Linton (Author/Creator) - Concord Repatriation General HospitalS. Klebe (Author/Creator) - Flinders Medical CentreB.C. McCaughan (Author/Creator) - Sydney Cardiothoracic Surgeons, RPA Medical Centre, Sydney, NSW, AustraliaN. van Zandwijk (Author/Creator) - The University of SydneyG. Reid (Author/Creator) - The University of Sydney
- Publication Details
- Molecular Oncology, Vol.9(3), pp.715-726
- Publisher
- Elsevier Ltd.
- Identifiers
- 991005542301307891
- Copyright
- © 2014 Federation of European Biochemical Societies
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.196 Micro & Long Noncoding RNA
- 1.196.68 MicroRNA in Cancer
- Web Of Science research areas
- Oncology
- ESI research areas
- Molecular Biology & Genetics