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CC BY V4.0, Open Access
Journal article
Micro-nanoplastic induced cardiovascular disease and dysfunction: a scoping review
Journal of exposure science & environmental epidemiology
2025
PMID: 40169912
Abstract
Background
The human bioaccumulation of micro- and nano-plastics (MNPs) is increasingly being recognised in the aetiology and pathophysiology of human disease.
Objective
This systematic scoping review aims to provide a comprehensive investigation of studies examining the impacts of MNPs on the human cardiovascular system.
Methods
Five databases (PubMed, SCOPUS, CINAHL, Web of Science and EMBASE) were systematically searched.
Results
Forty-six articles were identified, 13 of which investigated the presence of MNPs within the human cardiovascular system, including atherosclerotic plaques, saphenous vein tissue, thrombi and venous blood. The effect of MNPs on cell lines suggest MNPs are cytotoxic, immunotoxic, and genotoxic.
Significance
The findings of this review, when evaluated together with additional studies utilising animal models, suggest MNPs may contribute to global cardiovascular morbidity and mortality. In particular, the ability of MNPs to induce endothelial damage, oxy-LDL formation, foam cell development and apoptosis, as well as to alter the clotting cascade, has potential implications for vascular diseases. In addition, MNPs may play a role in the aetiology and progression of congenital heart abnormalities, infective pathologies and cardiomyopathies. Despite an increasing awareness of the ability for MNPs to result in cardiovascular disease and dysfunction, a limited amount of research has been conducted to date characterising the presence of MNPs in the human cardiovascular system. Reseach is required to understand the extent of this rapidly emerging issue and to develop strategies that will support clinicians to appropriately manage and educate their patients in the future.
Details
- Title
- Micro-nanoplastic induced cardiovascular disease and dysfunction: a scoping review
- Authors/Creators
- Adrian Goldsworthy - Bond UniversityLiam A O'Callaghan - Bond UniversityCiara Blum - Griffith UniversityJarod Horobin - Versiti Blood Center of WisconsinLotti Tajouri - Bond UniversityMatthew Olsen - Bond UniversityNatalia Van Der Bruggen - Bond UniversitySimon McKirdy - Murdoch University, Centre for Biosecurity and One HealthRashed Alghafri - Murdoch UniversityOystein Tronstad - Prince Charles HospitalJacky Suen - Prince Charles HospitalJohn F Fraser - Wesley Research Institute
- Publication Details
- Journal of exposure science & environmental epidemiology
- Publisher
- Springer Nature
- Number of pages
- 24
- Grant note
- CAUL
Open Access funding enabled and organized by CAUL and its Member Institutions.
- Identifiers
- 991005760733907891
- Copyright
- © The Author(s) 2025
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.60 Herbicides, Pesticides & Ground Poisoning
- 3.60.2078 Microplastics
- Web Of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology
- ESI research areas
- Environment/Ecology