Journal article
Microbiota from alginate oligosaccharide-dosed mice successfully mitigated small intestinal mucositis
Microbiome, Vol.8(1), Art. 112
2020
Abstract
Background
The increasing incidence of cancer and intestinal mucositis induced by chemotherapeutics are causing worldwide concern. Many approaches such as fecal microbiota transplantation (FMT) have been used to minimize mucositis. However, it is still unknown whether FMT from a donor with beneficial gut microbiota results in more effective intestinal function in the recipient. Recently, we found that alginate oligosaccharides (AOS) benefit murine gut microbiota through increasing “beneficial” microbes to rescue busulfan induced mucositis.
Results
In the current investigation, FMT from AOS-dosed mice improved small intestine function over FMT from control mice through the recovery of gene expression and an increase in the levels of cell junction proteins. FMT from AOS-dosed mice showed superior benefits over FMT from control mice on recipient gut microbiotas through an increase in “beneficial” microbes such as Leuconostocaceae and recovery in blood metabolome. Furthermore, the correlation of gut microbiota and blood metabolites suggested that the “beneficial” microbe Lactobacillales helped with the recovery of blood metabolites, while the “harmful” microbe Mycoplasmatales did not.
Conclusion
The data confirm our hypothesis that FMT from a donor with superior microbes leads to a more profound recovery of small intestinal function. We propose that gut microbiota from naturally produced AOS-treated donor may be used to prevent small intestinal mucositis induced by chemotherapeutics or other factors in recipients.
Details
- Title
- Microbiota from alginate oligosaccharide-dosed mice successfully mitigated small intestinal mucositis
- Authors/Creators
- P. Zhang (Author/Creator) - Qingdao Agricultural UniversityJ. Liu (Author/Creator) - Qingdao Agricultural UniversityB. Xiong (Author/Creator) - Qingdao Agricultural UniversityC. Zhang (Author/Creator) - Qingdao Agricultural UniversityB. Kang (Author/Creator) - Qingdao Agricultural UniversityY. Gao (Author/Creator) - Qingdao Agricultural UniversityZ. Li (Author/Creator) - Qingdao Agricultural UniversityW. Ge (Author/Creator) - Qingdao Agricultural UniversityS. Cheng (Author/Creator) - Qingdao Agricultural UniversityY. Hao (Author/Creator) - Qingdao Agricultural UniversityW. Shen (Author/Creator) - Qingdao Agricultural UniversityS. Yu (Author/Creator) - Peking University Shenzhen HospitalL. Chen (Author/Creator) - State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, People’s Republic of ChinaX. Tang (Author/Creator) - State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, People’s Republic of ChinaY. Zhao (Author/Creator) - Qingdao Agricultural UniversityH. Zhang (Author/Creator) - State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, People’s Republic of China
- Publication Details
- Microbiome, Vol.8(1), Art. 112
- Publisher
- BioMed Central Ltd as part of Springer Nature
- Identifiers
- 991005542850007891
- Copyright
- © 2020 The Authors.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.384 Gut Microbiota
- Web Of Science research areas
- Microbiology
- ESI research areas
- Microbiology