Mimicry between HTLV-I and myelin basic protein: no response in HTLV-I-associated myelopathy patients

J.M. Davies; S. Sonoda; S. Yashiki; M. Osame; P.R. Carnegie

doi:10.1016/0165-5728(92)90075-V

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Mimicry between HTLV-I and myelin basic protein: no response in HTLV-I-associated myelopathy patients

Journal article

Peer reviewed

Mimicry between HTLV-I and myelin basic protein: no response in HTLV-I-associated myelopathy patients

J.M. Davies, S. Sonoda, S. Yashiki, M. Osame and P.R. Carnegie

Journal of Neuroimmunology, Vol.41(2), pp.239-243

1992

DOI: https://doi.org/10.1016/0165-5728(92)90075-V

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Abstract

The reactivity to a peptide from the HTLV-I polyprotein (FKLPGLNSR) and a similar sequence from myelin basic protein (MBP) (FKLGGRDSR) was examined in relation to the proposal that mimicry of MBP by HTLV-I could be involved in autoimmune responses in HTLV-I-associated myelopathy (HAM). It was found that rabbit antibodies raised against the HTLV-I peptide recognised both peptides, with a titre of 1/10240 to the HTLV-I peptide and 1/5220 to the MBP peptide. Human sera from HAM patients and a HTLV-I carrier without HAM showed slightly higher responses to the HTLV-I peptide compared to the responses from uninfected human sera. HAM patients had greater responses to the HTLV-I peptide than to the similar MBP peptide and an unrelated bovine MBP peptide. There was no recognition of the peptides by peripheral blood lymphocytes from HAM patients or a HTLV-I carrier without HAM. It was concluded that although cross-reactivity was demonstrated in rabbits and the HTLV-I peptide was recognised by sera from HAM patients, the epitope does not appear to evoke a mimicking response to the similar region in MBP. Hence it is not likely to be involved in the pathogenesis of HAM through molecular mimicry.

Details

Title: Mimicry between HTLV-I and myelin basic protein: no response in HTLV-I-associated myelopathy patients
Authors/Creators: J.M. Davies (Author/Creator)
S. Sonoda (Author/Creator)
S. Yashiki (Author/Creator)
M. Osame (Author/Creator)
P.R. Carnegie (Author/Creator)
Publication Details: Journal of Neuroimmunology, Vol.41(2), pp.239-243
Publisher: Elsevier
Identifiers: 991005540863007891
Murdoch Affiliation: School of Biological and Environmental Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.1464 HTLV-1/BLV Pathogenesis
Web Of Science research areas: Immunology; Neurosciences
ESI research areas: Neuroscience & Behavior