Journal article
Minimising the development of anthelmintic resistance, and optimising the use of the novel anthelmintic monepantel, for the sustainable control of nematode parasites in Australian sheep grazing systems
Australian Veterinary Journal, Vol.89(5), pp.160-166
2011
Abstract
Objective To compare the risk of different treatment scenarios on selecting for anthelmintic resistance on Australian sheep farms.
Design A computer simulation model predicted populations of Trichostrongylus colubriformis, Haemonchus contortus or Teladorsagia (Ostertagia) circumcincta, and the frequency of anthelmintic resistance genes.
Method Nematode populations and the progression of drug resistance for a variety of treatment options and management practices in sheep-rearing areas of Western Australia (WA), Victoria (VIC) and New South Wales (NSW) were simulated. A scoring system was devised to measure the success of each option in delaying resistance to each anthelmintic and in controlling nematode populations.
Results The best option at all sites was combining the new anthelmintic (monepantel) with a triple mixture of benzimidazole, levamisole and abamectin (COM). The next best option was: in NSW, rotation at each treatment between monepantel, moxidectin and COM; in VIC, rotation at each treatment between monepantel and COM; and in WA, rotation at each treatment between monepantel (used in winter) and COM or moxidectin (used in summer-autumn). In WA, rapid selection for resistance occurred as a consequence of summer-autumn treatments; however, if a small percentage of adult stock were left untreated then this selection could be greatly reduced. Despite purposely assuming relatively high resistance to benzimidazole and levamisole, COM was still effective in controlling worms and delaying resistance.
Conclusions Because of cost constraints, it may not be feasible or profitable for producers to always use the combination of all drugs. However, the second-and third-best options still considerably slowed the development of anthelmintic resistance.
Details
- Title
- Minimising the development of anthelmintic resistance, and optimising the use of the novel anthelmintic monepantel, for the sustainable control of nematode parasites in Australian sheep grazing systems
- Authors/Creators
- R.J. Dobson (Author/Creator)B.C. Hosking (Author/Creator)R.B. Besier (Author/Creator)S. Love (Author/Creator)J.W.A. Larsen (Author/Creator)P.F. Rolfe (Author/Creator)J.N. Bailey (Author/Creator)
- Publication Details
- Australian Veterinary Journal, Vol.89(5), pp.160-166
- Publisher
- Wiley-Blackwell
- Identifiers
- 991005545004307891
- Copyright
- 2011 The Authors.
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
- Note
- ‘The definitive version is available at www.interscience.wiley.com’
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
430 File views/ downloads
97 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Industry collaboration
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.163 Parasitology - General
- 1.163.1022 Anthelmintic Resistance
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science