Modelling the co-occurrence of Streptococcus pneumoniae with other bacterial and viral pathogens in the upper respiratory tract

P. Jacoby; K. Watson; J. Bowman; A. Taylor; T.V. Riley; D.W. Smith; D. Lehmann

doi:10.1016/j.vaccine.2006.09.020

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Modelling the co-occurrence of Streptococcus pneumoniae with other bacterial and viral pathogens in the upper respiratory tract

Journal article

Peer reviewed

Modelling the co-occurrence of Streptococcus pneumoniae with other bacterial and viral pathogens in the upper respiratory tract

P. Jacoby, K. Watson, J. Bowman, A. Taylor, T.V. Riley, D.W. Smith and D. Lehmann

Vaccine, Vol.25(13), pp.2458-2464

2007

DOI: https://doi.org/10.1016/j.vaccine.2006.09.020

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Abstract

Otitis media (OM) is a major burden for all children, particularly for Australian Aboriginal children. Streptococcus pneumoniae, Moraxella catarrhalis, Haemophilus influenzae and viruses (including rhinovirus and adenovirus) are associated with OM. We investigated nasopharyngeal microbial interactions in 435 samples collected from 79 Aboriginal and 570 samples from 88 non-Aboriginal children in Western Australia. We describe a multivariate random effects model appropriate for analysis of longitudinal data, which enables the identification of two independent levels of correlation between pairs of pathogens. At the microbe level, rhinovirus infection was positively correlated with carriage of S. pneumoniae, H. influenzae and M. catarrhalis, and adenovirus with M. catarrhalis. Generally, there were positive associations between bacterial pathogens at both the host and microbe level. Positive viral-bacterial associations at the microbe level support previous findings indicating that viral infection can predispose an individual to bacterial carriage. Viral vaccines may assist in reducing the burden of bacterial disease.

Details

Title: Modelling the co-occurrence of Streptococcus pneumoniae with other bacterial and viral pathogens in the upper respiratory tract
Authors/Creators: P. Jacoby (Author/Creator)
K. Watson (Author/Creator)
J. Bowman (Author/Creator)
A. Taylor (Author/Creator)
T.V. Riley (Author/Creator)
D.W. Smith (Author/Creator)
D. Lehmann (Author/Creator)
Publication Details: Vaccine, Vol.25(13), pp.2458-2464
Publisher: Elsevier Ltd
Identifiers: 991005543936307891
Copyright: © 2006 Elsevier Ltd
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.347 Streptococcus Pneumoniae
Web Of Science research areas: Immunology; Medicine, Research & Experimental
ESI research areas: Immunology