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Journal article
Modified rush venom immunotherapy in dogs with Hymenoptera hypersensitivity
Veterinary dermatology, Vol.34(6), pp.532-542
2023
Abstract
Background
Hymenoptera envenomation occurs frequently in people and dogs and can trigger anaphylaxis. Venom immunotherapy (VIT) is the only preventive treatment for Hymenoptera hypersensitivity and is indicated for people with severe adverse reactions to insect stings. Rush VIT is an accelerated VIT protocol in people. This has not been reported in dogs.
Objectives
The objective of the study was to evaluate the safety of modified rush VIT.
Animals
Twenty client-owned dogs with Hymenoptera hypersensitivity based on a history of adverse reactions to Hymenoptera envenomation and a positive intradermal test to honey bee and/or paper wasp venom.
Materials and Methods
Dogs received incremental doses of venom via subcutaneous injection one day per week for three consecutive weeks until the maintenance dose was achieved. Vital signs were recorded every 30 min prior to venom administration. Adverse reactions were categorised as localised or grade I–IV systemic reactions.
Results
Nineteen of 20 dogs (95%) completed rush VIT. One dog experienced a grade III systemic adverse reaction and was withdrawn from the study. No adverse reactions occurred in 10 of 20 dogs (50%). Localised and grade I–II systemic reactions occurred in nine of 20 dogs (45%), including nausea (n = 5), injection site pruritus (n = 3) and diarrhoea and lethargy (n = 1).
Conclusions and Clinical Relevance
Modified rush VIT in dogs was well-tolerated and should be considered for dogs with Hymenoptera hypersensitivity. Larger studies are needed to evaluate the efficacy of VIT in dogs for preventing hypersensitivity reactions to insect stings.
Details
- Title
- Modified rush venom immunotherapy in dogs with Hymenoptera hypersensitivity
- Authors/Creators
- Alexandra Moore - Murdoch UniversityAmanda K. Burrows - Murdoch UniversityWayne S. Rosenkrantz - Animal Dermatology Clinic Tustin California USARudayna M. Ghubash - Marina Del Rey HospitalGiselle Hosgood - Murdoch University, School of Veterinary Medicine
- Publication Details
- Veterinary dermatology, Vol.34(6), pp.532-542
- Publisher
- John Wiley & Sons Ltd on behalf of ESVD and ACVD.
- Identifiers
- 991005593760507891
- Copyright
- © 2023 The Authors.
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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