Journal article
Modifying effects of HLA-DRB1 allele interactions on age at onset of multiple sclerosis in Western Australia
Multiple Sclerosis, Vol.16(1), pp.15-20
2010
Abstract
The contribution of genetic factors to the age at onset in multiple sclerosis is poorly understood. Our objective was to investigate the disease modifying effects of HLA-DRB1 alleles and allele interactions on age at onset of multiple sclerosis. High-resolution four-digit HLA-DRB1 genotyping was performed in a cohort of 461 multiple sclerosis patients from the Perth Demyelinating Diseases Database. Carriage of the HLA-DRB1*1501 risk allele was not significantly associated with age at onset but HLA-DRB1*0801 was associated with a later onset of the disease. The HLA-DRB1*0401 allele was associated with a reduced age at onset when combined with DRB1*1501 but may delay age at onset when combined with DRB1*0801. These findings indicate that epistatic interactions at the HLA-DRB1 locus have significant modifying effects on age at onset of multiple sclerosis and demonstrate the value of high-resolution genotyping in detecting such associations.
Details
- Title
- Modifying effects of HLA-DRB1 allele interactions on age at onset of multiple sclerosis in Western Australia
- Authors/Creators
- J-S Wu (Author/Creator) - The University of Western AustraliaW. Qiu (Author/Creator) - The University of Western AustraliaA. Castley (Author/Creator) - Royal Perth HospitalI. James (Author/Creator) - Royal Perth HospitalF.L. Mastaglia (Author/Creator) - Sir Charles Gairdner HospitalF.T Christiansen (Author/Creator) - The University of Western AustraliaW.M Carroll (Author/Creator) - Sir Charles Gairdner HospitalJ. Joseph (Author/Creator) - Sir Charles Gairdner HospitalA.G. Kermode (Author/Creator) - Sir Charles Gairdner Hospital
- Publication Details
- Multiple Sclerosis, Vol.16(1), pp.15-20
- Publisher
- SAGE Publications
- Identifiers
- 991005540364307891
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.203 Neuromuscular Disorders
- 1.203.147 Multiple Sclerosis
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior