Journal article
Modulation of corticomotor excitability by an I-wave intervention delivered during low-level voluntary contraction
Experimental Brain Research, Vol.208(2), pp.229-235
2011
Abstract
Transcranial magnetic stimulation (TMS) interventions that modulate cortical plasticity may achieve a more functional benefit if combined with neuro-rehabilitation therapies. With a TMS protocol targeting I-wave dynamics, it is possible to deliver stimuli while a subject performs a motor task, and this may more effectively target functional networks related to the task. However, the efficacy of this intervention during a simple task such as a low-level voluntary contraction is not known. We delivered paired-pulse TMS at an inter-pulse interval (IPI) of 1.5 ms for 15 min while subjects performed a 10 ± 2.5% voluntary contraction of the first dorsal interosseous (FDI) muscle and made motor evoked potential (MEP) amplitude and short-interval intracortical facilitation (SICF) curve measurements. Pre-intervention SICF curves showed only a single peak at 1.3–1.5 ms IPI. During the intervention, MEP amplitude steadily increased (P < 0.001) to 137 ± 13% of its initial value. After the intervention, SICF curves were increased in amplitude (P < 0.001) and later peaks emerged at 2.8 and 4.3 ms IPIs. A control experiment, replacing paired-pulse stimulation with single-pulse stimulation showed no effect on MEP amplitude (P = 0.951). We conclude that the I-wave intervention can be administered concurrently with a simple motor task and that it acts by increasing trans-synaptic efficacy across a number of I-waves. The ability to perform a motor task simultaneously with a TMS intervention could confer a degree of specificity to the induced excitability changes and may be beneficial for functional neuro-rehabilitation programs built around motor learning and retraining.
Details
- Title
- Modulation of corticomotor excitability by an I-wave intervention delivered during low-level voluntary contraction
- Authors/Creators
- B.I. Silbert (Author/Creator) - The University of Western AustraliaJ.T. Gibbons (Author/Creator) - The University of Western AustraliaR.H.F. Cash (Author/Creator)F.L. Mastaglia (Author/Creator) - The University of Western AustraliaG.W. Thickbroom (Author/Creator) - The University of Western Australia
- Publication Details
- Experimental Brain Research, Vol.208(2), pp.229-235
- Publisher
- Springer-Verlag Berlin Heidelberg
- Identifiers
- 991005542620007891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.811 Transcranial Magnetic Stimulation
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior