Journal article
Modulation of retinal arteriolar central reflection by APOE Genotype
Current Alzheimer Research, Vol.14(9), pp.916-923
2017
Abstract
Objective: This study investigated the retinal arteriolar central reflex (CR, the central reflection observed in photographs of retinal vessels), which may provide information about micro-vascular health in the retina and also the brain, due to the homology between these vascular networks. The study also describes a novel computer based semi-automated technique that accurately quantifies retinal arteriolar CR and vessel width, and calculates the CR to vessel width ratio (CRR) from digital retinal photographs.
Methods: Digital retinal photographs were collected from participants in the Australian Imaging, Biomarkers and Lifestyle study of ageing (AIBL), including 25 participants diagnosed with Alzheimer’s disease (AD) (age 72.4 ± 7.5 yrs, 12 male, 13 female) and 123 elderly participants without dementia (cognitively normals: CN) (age 71.6 ± 5.6 yrs, 55 male, 68 female). Using a sub-cohort of 144 (22 AD, 122 CN) with the novel CRR measures, we identified significantly higher CRR levels in AD participants (mean CRR 0.253 (SD 0.04)) as compared with CN’s (mean CRR 0.231 (SD 0.04), p = 0.025). Adjustment for APOE ε4 allele status however, reduced the significance (p = 0.081). CRR was significantly higher in APOE ε4 allele carriers (mean CRR 0.254 (SD 0.03) as compared with non-carriers (mean CRR 0.224 (SD 0.05), p < 0.0001).
Results: These data indicate that CRR is strongly linked to APOE ε4 status and exhibits a weaker, independent trend with AD diagnosis. The retina may be useful as a novel model for non-invasive monitoring of the effects of APOE ε4 on the central nervous system, particularly in cerebrovascular disease.
Details
- Title
- Modulation of retinal arteriolar central reflection by APOE Genotype
- Authors/Creators
- S. Frost (Author/Creator) - Australian e-Health Research CentreA. Bhuiyan (Author/Creator) - Australian e-Health Research CentreD. Offerman (Author/Creator) - Albany Medical Center HospitalJ.D. Doecke (Author/Creator) - Australian e-Health Research CentreS.L. Macaulay (Author/Creator) - Commonwealth Scientific and Industrial Research OrganisationH.R. Sohrabi (Author/Creator) - Australian Alzheimer’s Research FoundationD. Ames (Author/Creator) - National Ageing Research InstituteC. Masters (Author/Creator) - Mental Health Research InstituteR.N. Martins (Author/Creator) - Edith Cowan UniversityY. Kanagasingam (Author/Creator) - Australian e-Health Research Centre
- Publication Details
- Current Alzheimer Research, Vol.14(9), pp.916-923
- Publisher
- Bentham Science Publishers
- Identifiers
- 991005544862807891
- Copyright
- © 2017 Bentham Science Publishers
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 4 Electrical Engineering, Electronics & Computer Science
- 4.17 Computer Vision & Graphics
- 4.17.1752 Retinal Image Analysis
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior