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Molecular characterization of a novel, serologically detectable, HLA-C allele: Cw∗1602
Journal article   Peer reviewed

Molecular characterization of a novel, serologically detectable, HLA-C allele: Cw∗1602

C. Vilches, M.J. Herrero, R. de Pablo, M.E. Moreno, M. Bunce and M. Kreisler
Human Immunology, Vol.41(2), pp.167-170
1994
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Abstract

Cw∗1602, a novel HLA-C allele belonging to the newly assigned Cw∗16 group, has been cloned and sequenced from a Spanish Caucasoid cell expressing a “Cw6.2” phenotype. Some of the polymorphic substitutions of the new allele, and linkage disequilibrium to B51, had been predicted on the basis of previously published studies. The primary structure of Cw∗1602 is in agreement with its serologic reactivity and, in comparison with that of Cw∗1601, underlines the dimorphism of HLA-C molecules at residues 77 and 80 of the α1-domain α helix.

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Citation topics
1 Clinical & Life Sciences
1.6 Immunology
1.6.607 MHC Diversity
Web Of Science research areas
Immunology
ESI research areas
Immunology
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