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Published (Version of Record)CC BY V4.0, Open Access
Journal article
Molecular characterization of blaNDM-harboring plasmids reveal its rapid adaptation and evolution in the Enterobacteriaceae
One Health Advances, Vol.1(1), 30
2023
Abstract
Carbapenem is one of the few available drugs to treat multidrug-resistance Gram-negative bacteria infections. Recently, the plasmid-mediated spread of the carbapenem resistance gene blaNDM poses a significant threat to public health, requiring global monitoring and surveillance. Here, we used both short-read (n = 2461) and long-read (n = 546) sequencing data to characterize the global distribution of blaNDM. We analyzed the replicon type of blaNDM-positive plasmids and found that the dominant plasmid type was different in diverse geographical locations. Although blaNDM gene has been transferred across diverse countries, its genetic backgrounds are highly conserved, and the mobile genetic element ISAba125, IS5, and IS26 may play an important role in the mobilization of blaNDM. A significant association was observed between host origin and gene presence/deletion variation on IncX3 plasmid, which may be a key factor in the bacterial adaption to diverse hosts. In this study, we analyzed the diversity, distribution and transmission of blaNDM-positive plasmids from a global perspective, and emphasize the importance of plasmid analysis for understanding the evolution and adaptation of blaNDM-positive plasmids and their co-evolution with bacterial genomes (resistome).
Details
- Title
- Molecular characterization of blaNDM-harboring plasmids reveal its rapid adaptation and evolution in the Enterobacteriaceae
- Authors/Creators
- Yiming Li - Jiangsu Academy of Agricultural SciencesYuying Yang - Wenzhou Vocational College of Science and TechnologyYifei Wang - Key Laboratory of Guangdong ProvinceTimothy R. Walsh - University of OxfordShaolin Wang - Key Laboratory of Guangdong ProvinceChang Cai - Murdoch University
- Publication Details
- One Health Advances, Vol.1(1), 30
- Publisher
- BioMed Central Ltd unless otherwise stated. Part of Springer Nature.
- Identifiers
- 991005623530907891
- Copyright
- © The Author(s) 2023.
- Murdoch Affiliation
- Centre for Biosecurity and One Health
- Language
- English
- Resource Type
- Journal article
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