Journal article
Molecular cloning of two new HLA-C alleles: Cw*1801 and Cw*0706
Tissue Antigens, Vol.48(6), pp.698-702
1996
Abstract
Nucleotide sequence analysis of the HLA-C alleles of the GB92 cell line, heterozygous for B*8101 and B*4407, revealed the existence of two new allelic variants: Cw*1801 and Cw*0706. The former allele, initially detected as a PCR-SSP variant, displays a hybrid aspect, sharing sequence motifs with Cw*07 at exons 1 and 2, and with'Cw*04 at distal exons. In serological assays, Cw*1801 is only recognized by some cross-reactive sera. Cw*0706 shows a primary structure closely related to previously known Cw7 alleles, but carries new sequence motifs at its 3′-end. Preliminary data indicate that Cw*1801 is associated to B*8101 and that Cw*0706, B*4407 could account for a part of the Cw7, B44 haplotypes observed in African populations.
Details
- Title
- Molecular cloning of two new HLA-C alleles: Cw*1801 and Cw*0706
- Authors/Creators
- C. Vilches (Author/Creator)M. Bunce (Author/Creator)L. Sanz (Author/Creator)R. Pablo (Author/Creator)S. Puente (Author/Creator)M. Kreisler (Author/Creator)
- Publication Details
- Tissue Antigens, Vol.48(6), pp.698-702
- Publisher
- Blackwell Publishing
- Identifiers
- 991005540811707891
- Copyright
- 1996 Munksgaard
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.607 MHC Diversity
- Web Of Science research areas
- Cell Biology
- Immunology
- Pathology
- ESI research areas
- Molecular Biology & Genetics