Molecular epidemiology of methicillin-resistant Staphylococcus aureus isolated from Australian veterinarians

M.D. Groves; B. Crouch; G.W. Coombs; D. Jordan; S. Pang; M.D. Barton; P. Giffard; S. Abraham; D.J. Trott

doi:10.1371/journal.pone.0146034

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Molecular epidemiology of methicillin-resistant Staphylococcus aureus isolated from Australian veterinarians

Journal article

Open access

Peer reviewed

Molecular epidemiology of methicillin-resistant Staphylococcus aureus isolated from Australian veterinarians

M.D. Groves, B. Crouch, G.W. Coombs, D. Jordan, S. Pang, M.D. Barton, P. Giffard, S. Abraham and D.J. Trott

PLoS ONE, Vol.11(1), Article e0146034

2016

DOI: https://doi.org/10.1371/journal.pone.0146034

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Abstract

This work investigated the molecular epidemiology and antimicrobial resistance of methicillinresistant Staphylococcus aureus (MRSA) isolated from veterinarians in Australia in 2009. The collection (n = 44) was subjected to extensive molecular typing (MLST, spa, SCCmec, dru, PFGE, virulence and antimicrobial resistance genotyping) and antimicrobial resistance phenotyping by disk diffusion. MRSA was isolated from Australian veterinarians representing various occupational emphases. The isolate collection was dominated by MRSA strains belonging to clonal complex (CC) 8 and multilocus sequence type (ST) 22. CC8 MRSA (ST8-IV [2B], spa t064; and ST612-IV [2B], spa variable,) were strongly associated with equine practice veterinarians (OR = 17.5, 95% CI = 3.3-92.5, P < 0.001) and were often resistant to gentamicin and rifampicin. ST22-IV [2B], spa variable, were strongly associated with companion animal practice veterinarians (OR = 52.5, 95% CI = 5.2-532.7, P < 0.001) and were resistant to ciprofloxacin. A single pig practice veterinarian carried ST398-V [5C2], spa t1451. Equine practice and companion animal practice veterinarians frequently carried multiresistant-CC8 and ST22 MRSA, respectively, whereas only a single swine specialist carried MRSA ST398. The presence of these strains in veterinarians may be associated with specific antimicrobial administration practices in each animal species.

Details

Title: Molecular epidemiology of methicillin-resistant Staphylococcus aureus isolated from Australian veterinarians
Authors/Creators: M.D. Groves (Author/Creator) - Murdoch University
B. Crouch (Author/Creator) - University of South Australia
G.W. Coombs (Author/Creator) - Fiona Stanley Hospital
D. Jordan (Author/Creator) - New South Wales Department of Primary Industries
S. Pang (Author/Creator) - Fiona Stanley Hospital
M.D. Barton (Author/Creator) - University of South Australia
P. Giffard (Author/Creator) - Menzies School of Health Research
S. Abraham (Author/Creator) - Murdoch University
D.J. Trott (Author/Creator) - The University of Adelaide
Publication Details: PLoS ONE, Vol.11(1), Article e0146034
Publisher: Public Library of Science
Identifiers: 991005542921207891
Copyright: © 2016 Groves et al.
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.173 MRSA and VRE
Web Of Science research areas: Microbiology
ESI research areas: Immunology