Journal article
Molecular markers predict outcome in squamous cell carcinoma of the head and neck after concomitant cisplatin-based chemoradiation
International Journal of Cancer, Vol.124(11), pp.2643-2650
2009
Abstract
Not all patients with squamous cell carcinomas of the head and neck (HNSCC) benefit from concurrent cisplatin-based chemoradiation, but reliable predictive markers for outcome after chemoradiation are scarce. We have investigated potential prognostic biomarkers for outcome in a large group of patients. Ninety-one tumor biopsies taken from consecutive HNSCC patients were evaluated for protein expression on a tissue microarray. Using immunohistochemistry, 18 biomarkers, involved in various cellular pathways were investigated. Univariable and multivariable proportional hazard analyses were performed to investigate associations between each individual marker and outcome. In addition, the global test was used to test all variables simultaneously and selected combinations of markers for an overall association with local control. Univariable analysis showed statistically significant increased relative risks of RB, P16 and MRP2 for local control and MDR1 and HIF-1α for overall survival. MRP2, MDR1 and P16 levels were positively associated with outcome whereas RB and HIF-1α had a negative relationship. Using Goeman's global testing no combination of markers was identified that was associated with local control. Grouping the markers according to their function revealed an association between a combination of 3 markers (P16, P21 and P27) and outcome (p = 0.05) was found. In the multivariable analysis, MRP2 and RB remained significant independent predictive markers for local control. This study describes the prognostic value of biomarkers for the outcome in patients uniformly treated with concurrent chemoradiation. MRP2 and RB were found to be associated with outcome in patients treated with concurrent chemoradiation.
Details
- Title
- Molecular markers predict outcome in squamous cell carcinoma of the head and neck after concomitant cisplatin-based chemoradiation
- Authors/Creators
- G.B. van den Broek (Author/Creator) - The Netherlands Cancer InstituteM. Wildeman (Author/Creator) - The Netherlands Cancer InstituteC.R.N. Rasch (Author/Creator) - The Netherlands Cancer InstituteN. Armstrong (Author/Creator) - The Netherlands Cancer InstituteE. Schuuring (Author/Creator) - Drug Abuse Resistance EducationA.C. Begg (Author/Creator) - The Netherlands Cancer InstituteL.H.J. Looijenga (Author/Creator) - Erasmus University RotterdamR. Scheper (Author/Creator) - Vrije Universiteit AmsterdamJ.E. van der Wal (Author/Creator) - University Medical Center GroningenL. Menkema (Author/Creator) - University Medical Center GroningenP.J. van Diest (Author/Creator) - Utrecht UniversityA.J.M. Balm (Author/Creator) - The Netherlands Cancer InstituteM-L.F. van Velthuysen (Author/Creator) - The Netherlands Cancer InstituteM.W.M. van den Brekel (Author/Creator)
- Publication Details
- International Journal of Cancer, Vol.124(11), pp.2643-2650
- Publisher
- Wiley-Liss Inc.
- Identifiers
- 991005544051607891
- Copyright
- © 2009 Wiley-Liss, Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
28 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.179 Oncology
- 1.179.377 Head And Neck Cancer
- Web Of Science research areas
- Oncology
- ESI research areas
- Clinical Medicine