Journal article
Molecular mechanisms of HIV Type 1 prophylaxis failure revealed by Single-genome sequencing
Journal of Infectious Diseases, Vol.208(10), pp.1598-1603
2013
Abstract
Trials of HIV-1 pre- and post-exposure prophylaxis show promise. Here, we describe a novel strategy for deciphering mechanisms of prophylaxis failure that could improve therapeutic outcomes. A healthcare worker began antiretroviral prophylaxis immediately after a high-risk needlestick injury but nonetheless became viremic 11 weeks later. Single genome sequencing of plasma viral RNA identified 15 drug-sensitive transmitted/founder HIV-1 genomes responsible for productive infection. Sequences emanating from these genomes exhibited extremely low diversity, suggesting virus sequestration as opposed to low-level replication as the cause of breakthrough infection. Identification of transmitted/founder viruses allows for genome-wide assessment of molecular mechanisms of prophylaxis failure.
Details
- Title
- Molecular mechanisms of HIV Type 1 prophylaxis failure revealed by Single-genome sequencing
- Authors/Creators
- H. Li (Author/Creator) - University of PennsylvaniaL. Blair (Author/Creator) - Los Alamos National LaboratoryY. Chen (Author/Creator) - University of Alabama at BirminghamG. Learn (Author/Creator) - University of PennsylvaniaK. Pfafferott (Author/Creator) - Murdoch UniversityM. John (Author/Creator) - Murdoch UniversityT. Bhattacharya (Author/Creator) - Los Alamos National LaboratoryB.H. Hahn (Author/Creator) - University of PennsylvaniaS. Mallal (Author/Creator) - Murdoch UniversityG.M. Shaw (Author/Creator) - University of PennsylvaniaK.J. Bar (Author/Creator) - University of Pennsylvania
- Publication Details
- Journal of Infectious Diseases, Vol.208(10), pp.1598-1603
- Publisher
- Oxford University Press
- Identifiers
- 991005543249107891
- Copyright
- © The Author 2013
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
234 File views/ downloads
32 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.46 HIV Pathogenesis
- Web Of Science research areas
- Immunology
- Infectious Diseases
- Microbiology
- ESI research areas
- Immunology