Journal article
Molecular model of Prion transmission to humans
Emerging infectious diseases, Vol.15(12), pp.2013-2016
2009
Abstract
To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.
Details
- Title
- Molecular model of Prion transmission to humans
- Authors/Creators
- M. Jones (Author/Creator) - Western General HospitalD. Wight (Author/Creator) - Institut du CerveauR. Barron (Author/Creator) - Royal (Dick) School of Veterinary StudiesM. Jeffrey (Author/Creator) - LFB (France)J. Manson (Author/Creator) - Royal (Dick) School of Veterinary StudiesC. Prowse (Author/Creator) - University of EdinburghJ.W. Ironside (Author/Creator) - Deanery of Molecular, Genetic and Population Health Sciences, Centre for Clinical Brain SciencesM.W. Head (Author/Creator) - Deanery of Molecular, Genetic and Population Health Sciences, Centre for Clinical Brain Sciences
- Publication Details
- Emerging infectious diseases, Vol.15(12), pp.2013-2016
- Publisher
- Centers for Disease Control and Prevention (CDC)
- Identifiers
- 991005540877307891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.992 Prion Pathogenesis
- Web Of Science research areas
- Immunology
- Infectious Diseases
- ESI research areas
- Immunology