Journal article
Morbidity from in-hospital complications is greater than treatment failure in patients with Staphylococcus aureus bacteraemia
BMC Infectious Diseases, Vol.18(1), Art. 107
2018
Abstract
Background: Various studies have identified numerous factors associated with poor clinical outcomes in patients with Staphylococcus aureus bacteraemia (SAB). A new study was created to provide deeper insight into in-hospital complications and risk factors for treatment failure.
Methods: Adult patients hospitalised with Staphylococcus aureus bacteraemia (SAB) were recruited prospectively into a multi-centre cohort. The primary outcome was treatment failure at 30 days (composite of all-cause mortality, persistent bacteraemia, or recurrent bacteraemia), and secondary measures included in-hospital complications and mortality at 6- and 12-months. Data were available for 222 patients recruited from February 2011 to December 2012.
Results: Treatment failure at 30-days was recorded in 14.4% of patients (30-day mortality 9.5%). Multivariable analysis predictors of treatment failure included age > 70 years, Pitt bacteraemia score ≥ 2, CRP at onset of SAB > 250 mg/L, and persistent fevers after SAB onset; serum albumin at onset of SAB, receipt of appropriate empiric treatment, recent healthcare attendance, and performing echocardiography were protective. 6-month and 12-month mortality were 19.1% and 24.2% respectively. 45% experienced at least one in-hospital complication, including nephrotoxicity in 19.5%.
Conclusions: This study demonstrates significant improvements in 30-day outcomes in SAB in Australia. However, we have identified important areas to improve outcomes from SAB, particularly reducing renal dysfunction and in-hospital treatment-related complications.
Details
- Title
- Morbidity from in-hospital complications is greater than treatment failure in patients with Staphylococcus aureus bacteraemia
- Authors/Creators
- N.E. Holmes (Author/Creator) - The University of MelbourneJ.O. Robinson (Author/Creator) - Curtin UniversityS.J. van Hal (Author/Creator) - Royal Prince Alfred HospitalW.J. Munckhof (Author/Creator) - The University of QueenslandE. Athan (Author/Creator) - Barwon HealthT.M. Korman (Author/Creator) - Monash UniversityA.C. Cheng (Author/Creator) - Monash UniversityJ.D. Turnidge (Author/Creator) - The University of AdelaideP.D.R. Johnson (Author/Creator) - The University of MelbourneB.P. Howden (Author/Creator) - Austin Health
- Publication Details
- BMC Infectious Diseases, Vol.18(1), Art. 107
- Publisher
- BioMed Central
- Identifiers
- 991005543919607891
- Copyright
- © 2018 The Authors.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
- Additional Information
- VANESSA study group, on behalf of the Australasian Society for Infectious Diseases (ASID) Clinical Research Network (CRN)
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.173 MRSA and VRE
- Web Of Science research areas
- Infectious Diseases
- ESI research areas
- Immunology