Journal article
Morphological characterization of Cryptosporidium parvum life-cycle stages in an in vitro model system
Parasitology, Vol.137(01), pp.13-26
2010
Abstract
Cryptosporidium parvum is a zoonotic protozoan parasite that mainly affects the ileum of humans and livestock, with the potential to cause severe enteric disease. We describe the complete life cycle of C. parvum in an in vitro system. Infected cultures of the human ileocecal epithelial cell line (HCT-8) were observed over time using electron microscopy. Additional data are presented on the morphology, development and behavioural characteristics of the different life-cycle stages as well as determining their time of occurrence after inoculation. Numerous stages of C. parvum and their behaviour have been visualized and morphologically characterized for the first time using scanning electron microscopy. Further, parasite-host interactions and the effect of C. parvum on host cells were also visualized. An improved understanding of the parasite's biology, proliferation and interactions with host cells will aid in the development of treatments for the disease.
Details
- Title
- Morphological characterization of Cryptosporidium parvum life-cycle stages in an in vitro model system
- Authors/Creators
- H. Borowski (Author/Creator)R.C.A. Thompson (Author/Creator)T. Armstrong (Author/Creator)P.L. Clode (Author/Creator)
- Publication Details
- Parasitology, Vol.137(01), pp.13-26
- Publisher
- Cambridge University Press
- Identifiers
- 991005540401107891
- Copyright
- © 2009 Cambridge University Press
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.246 Diarrheal Diseases
- 1.246.985 Cryptosporidium
- Web Of Science research areas
- Parasitology
- ESI research areas
- Microbiology