Mouse Anesthesia: The Art and Science

K.L. Navarro; M. Huss; J.C. Smith; P. Sharp; J.O. Marx; C. Pacharinsak

doi:10.1093/ilar/ilab016

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Journal article

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Peer reviewed

Mouse Anesthesia: The Art and Science

K.L. Navarro, M. Huss, J.C. Smith, P. Sharp, J.O. Marx and C. Pacharinsak

ILAR Journal, Vol.62(1-2), pp.238-273

2021

DOI: https://doi.org/10.1093/ilar/ilab016

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Abstract

There is an art and science to performing mouse anesthesia, which is a significant component to animal research. Frequently, anesthesia is one vital step of many over the course of a research project spanning weeks, months, or beyond. It is critical to perform anesthesia according to the approved research protocol using appropriately handled and administered pharmaceutical-grade compounds whenever possible. Sufficient documentation of the anesthetic event and procedure should also be performed to meet the legal, ethical, and research reproducibility obligations. However, this regulatory and documentation process may lead to the use of a few possibly oversimplified anesthetic protocols used for mouse procedures and anesthesia. Although a frequently used anesthetic protocol may work perfectly for each mouse anesthetized, sometimes unexpected complications will arise, and quick adjustments to the anesthetic depth and support provided will be required. As an old saying goes, anesthesia is 99% boredom and 1% sheer terror. The purpose of this review article is to discuss the science of mouse anesthesia together with the art of applying these anesthetic techniques to provide readers with the knowledge needed for successful anesthetic procedures. The authors include experiences in mouse inhalant and injectable anesthesia, peri-anesthetic monitoring, specific procedures, and treating common complications. This article utilizes key points for easy access of important messages and authors’ recommendation based on the authors’ clinical experiences.

Details

Title: Mouse Anesthesia: The Art and Science
Authors/Creators: K.L. Navarro (Author/Creator) - Stanford University
M. Huss (Author/Creator) - Stanford University
J.C. Smith (Author/Creator) - Henry Ford Health System
P. Sharp (Author/Creator) - University of California, Merced
J.O. Marx (Author/Creator) - University of Pennsylvania
C. Pacharinsak (Author/Creator) - Stanford University
Publication Details: ILAR Journal, Vol.62(1-2), pp.238-273
Publisher: Oxford Academic
Identifiers: 991005545313407891
Copyright: © 2021 The Authors.
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

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Highly Cited Paper

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.43 Anesthesiology; 1.43.1642 Veterinary Anesthesia
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science