Mouse models of ageing and their relevance to disease

S. Kõks; S. Dogan; B.G. Tuna; H. González-Navarro; P. Potter; R.E. Vandenbroucke

doi:10.1016/j.mad.2016.10.001

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Mouse models of ageing and their relevance to disease

Journal article

Open access

Peer reviewed

Mouse models of ageing and their relevance to disease

S. Kõks, S. Dogan, B.G. Tuna, H. González-Navarro, P. Potter and R.E. Vandenbroucke

Mechanisms of Ageing and Development, Vol.160, pp.41-53

2016

DOI: https://doi.org/10.1016/j.mad.2016.10.001

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Abstract

Ageing is a process that gradually increases the organism’s vulnerability to death. It affects different biological pathways, and the underlying cellular mechanisms are complex. In view of the growing disease burden of ageing populations, increasing efforts are being invested in understanding the pathways and mechanisms of ageing. We review some mouse models commonly used in studies on ageing, highlight the advantages and disadvantages of the different strategies, and discuss their relevance to disease susceptibility. In addition to addressing the genetics and phenotypic analysis of mice, we discuss examples of models of delayed or accelerated ageing and their modulation by caloric restriction.

Details

Title: Mouse models of ageing and their relevance to disease
Authors/Creators: S. Kõks (Author/Creator) - Estonian University of Life Sciences
S. Dogan (Author/Creator) - Yeditepe University
B.G. Tuna (Author/Creator)
H. González-Navarro (Author/Creator) - Institute of Health Research-INCLIVA, 46010 Valencia, Spain and CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), 28029 Madrid, Spain
P. Potter (Author/Creator) - Mary Lyon Centre at MRC Harwell
R.E. Vandenbroucke (Author/Creator) - Ghent University
Publication Details: Mechanisms of Ageing and Development, Vol.160, pp.41-53
Publisher: Elsevier
Identifiers: 991005543203707891
Copyright: © 2016 The Authors.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.264 Longevity; 1.264.618 Aging Mechanisms
Web Of Science research areas: Cell Biology; Geriatrics & Gerontology
ESI research areas: Molecular Biology & Genetics