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Open Access CC BY-NC-ND V4.0
Journal article
Multi night digital assessment of sleep disordered breathing is associated with accelerated vascular aging
NPJ digital medicine, Vol.9(1), 286
2026
PMID: 41741783
Abstract
Pulse wave velocity (PWV) is a marker of vascular aging and cardiovascular risk. Obstructive sleep apnea (OSA) may accelerate vascular decline, but evidence from single-night assessments is inconsistent. We examined associations of multi-night OSA severity, night-to-night variability, and snoring with arterial stiffness in a real-world setting. Adults used two in-home digital devices over a ~ 4 y period: an under-mattress sleep sensor to quantify nightly OSA severity and snoring, and a smart scale to measure aortic-leg PWV. Among 29,653 participants from 20 countries (52 ± 12 years; 84% male; BMI 27.3 ± 4.9 kg/m
), increasing OSA severity was associated with higher PWV in a dose-response manner, independent of age, sex, and BMI. Participants with mild OSA but high variability had PWV levels comparable to severe OSA. Higher snoring burden independently predicted higher PWV across OSA severity categories. Multi-night in-home assessments of OSA and snoring may better reflect cardiovascular risk with potential to inform personalized management.
Details
- Title
- Multi night digital assessment of sleep disordered breathing is associated with accelerated vascular aging
- Authors/Creators
- Lucía Pinilla - Adelaide Institute for Sleep HealthKelly Sansom - Murdoch University, Centre for Healthy AgeingPhilomène Letzelter - École de Formation Professionnelle des Barreaux de la Cour d'Appel de ParisAndrew Vakulin - Adelaide Institute for Sleep HealthAshley Montero - Adelaide Institute for Sleep HealthAnna Hudson - Adelaide Institute for Sleep HealthPierre Escourrou - Center for Research and InterdisciplinarityJean-Louis Pepin - Université Grenoble AlpesRobert Adams - Adelaide Institute for Sleep HealthPeter Catcheside - Flinders UniversityBastien Lechat - Adelaide Institute for Sleep HealthDanny J Eckert - Adelaide Institute for Sleep Health
- Publication Details
- NPJ digital medicine, Vol.9(1), 286
- Publisher
- Springer Nature
- Number of pages
- 9
- Identifiers
- 991005877054607891
- Copyright
- © The Author(s) 2026
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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