Multiplatform plasma metabolic and lipid fingerprinting of breast cancer: A pilot control-case study in Colombian Hispanic women

Monica P. Cala; Julian Aldana; Jessica Medina; Julian Sanchez; Jose Guio; Julien Wist; Roland J. W. Meesters

doi:10.1371/journal.pone.0190958

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Multiplatform plasma metabolic and lipid fingerprinting of breast cancer: A pilot control-case study in Colombian Hispanic women

Journal article

Open access

Peer reviewed

Multiplatform plasma metabolic and lipid fingerprinting of breast cancer: A pilot control-case study in Colombian Hispanic women

Monica P. Cala, Julian Aldana, Jessica Medina, Julian Sanchez, Jose Guio, Julien Wist and Roland J. W. Meesters

PloS one, Vol.13(2), e0190958

2018

DOI: https://doi.org/10.1371/journal.pone.0190958

PMCID: PMC5810980

PMID: 29438405

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Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Breast cancer (BC) is a highly heterogeneous disease associated with metabolic reprogramming. The shifts in the metabolome caused by BC still lack data from Latin populations of Hispanic origin. In this pilot study, metabolomic and lipidomic approaches were performed to establish a plasma metabolic fingerprint of Colombian Hispanic women with BC. Data from 1 H-NMR, GC-MS and LC-MS were combined and compared. Statistics showed discrimination between breast cancer and healthy subjects on all analytical platforms. The differentiating metabolites were involved in glycerolipid, glycerophospholipid, amino acid and fatty acid metabolism. This study demonstrates the usefulness of multiplatform approaches in metabolic/lipid fingerprinting studies to broaden the outlook of possible shifts in metabolism. Our findings propose relevant plasma metabolites that could contribute to a better understanding of underlying metabolic shifts driven by BC in women of Colombian Hispanic origin. Particularly, the understanding of the up-regulation of long chain fatty acyl carnitines and the down-regulation of cyclic phosphatidic acid (cPA). In addition, the mapped metabolic signatures in breast cancer were similar but not identical to those reported for non-Hispanic women, despite racial differences.

Details

Title: Multiplatform plasma metabolic and lipid fingerprinting of breast cancer: A pilot control-case study in Colombian Hispanic women
Authors/Creators: Monica P. Cala - Universidad de Los Andes
Julian Aldana - Universidad de Los Andes
Jessica Medina - Universidad del Valle
Julian Sanchez - Liga Canc Secc Bogota, Bogota, Colombia
Jose Guio - Liga Canc Secc Bogota, Bogota, Colombia
Julien Wist - Universidad del Valle
Roland J. W. Meesters - Universidad de Los Andes
Publication Details: PloS one, Vol.13(2), e0190958
Publisher: Public Library of Science
Number of pages: 23
Grant note: 2015-1 / Proyecto Semilla from the Faculty of Sciences of Universidad de los Andes, Bogota D.C., Colombia
Identifiers: 991005616561907891
Murdoch Affiliation: Centre for Computational and Systems Medicine
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 2 Chemistry; 2.211 Mass Spectrometry; 2.211.990 Metabolomics
Web Of Science research areas: Oncology
ESI research areas: Clinical Medicine