Multiple effects of physical activity on molecular and cognitive signs of brain aging: Can exercise slow neurodegeneration and delay Alzheimer’s disease?

B.M. Brown; J.J. Peiffer; R.N. Martins

doi:10.1038/mp.2012.162

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Multiple effects of physical activity on molecular and cognitive signs of brain aging: Can exercise slow neurodegeneration and delay Alzheimer’s disease?

Journal article

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Peer reviewed

Multiple effects of physical activity on molecular and cognitive signs of brain aging: Can exercise slow neurodegeneration and delay Alzheimer’s disease?

B.M. Brown, J.J. Peiffer and R.N. Martins

Molecular Psychiatry, Vol.18(8), pp.864-874

2013

DOI: https://doi.org/10.1038/mp.2012.162

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Abstract

Western countries are experiencing aging populations and increased longevity; thus, the incidence of dementia and Alzheimer’s disease (AD) in these countries is projected to soar. In the absence of a therapeutic drug, non-pharmacological preventative approaches are being investigated. One of these approaches is regular participation in physical activity or exercise. This paper reviews studies that have explored the relationship between physical activity and cognitive function, cognitive decline, AD/dementia risk and AD-associated biomarkers and processes. There is now strong evidence that links regular physical activity or exercise to higher cognitive function, decreased cognitive decline and reduced risk of AD or dementia. Nevertheless, these associations require further investigation, more specifically with interventional studies that include long follow-up periods. In particular, relatively little is known about the underlying mechanism(s) of the associations between physical activity and AD neuropathology; clearly this is an area in need of further research, particularly in human populations. Although benefits of physical activity or exercise are clearly recognised, there is a need to clarify how much physical activity provides the greatest benefit and also whether people of different genotypes require tailored exercise regimes.

Details

Title: Multiple effects of physical activity on molecular and cognitive signs of brain aging: Can exercise slow neurodegeneration and delay Alzheimer’s disease?
Authors/Creators: B.M. Brown (Author/Creator) - The University of Western Australia
J.J. Peiffer (Author/Creator) - Murdoch University
R.N. Martins (Author/Creator) - Edith Cowan University
Publication Details: Molecular Psychiatry, Vol.18(8), pp.864-874
Publisher: Macmillan Publishers Limited
Identifiers: 991005544370107891
Murdoch Affiliation: School of Chiropractic and Sports Science
Language: English
Resource Type: Journal article
Publisher URL: http://www.nature.com/mp/index.html

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.60 Dementia
Web Of Science research areas: Biochemistry & Molecular Biology; Neurosciences; Psychiatry
ESI research areas: Neuroscience & Behavior