Journal article
Multiple forms of glucagon and somatostatin isolated from the intestine of the Southern-Hemisphere Lamprey Geotria australis
General and Comparative Endocrinology, Vol.113(2), pp.274-282
1999
Abstract
Current views on Agnathan phylogeny favor the hypothesis that the genera of holarctic lampreys belong to a single family (Petromyzontidae) and form an interrelated progression in which Petromyzon is near to Ichthomyzon at the base of the phylogenetic tree and Lainpetra is the most derived. A stock similar to that of contemporary Ichthomyzon is considered to have given rise to the southern hemisphere lamprey Geotria australis, the sole member of the Geotriidae. In the present study, two molecular forms of glucagon were isolated from an extract of G. australis intestine that differed in structure by six amino acid residues. One form shows two amino acid substitutions (Leu14 → Met and Ala29 → Ser) compared with the single molecular form of glucagon isolated from the sea lamprey Petromyzon marinus and the second form shows three substitutions (Asp15 → Glu, Ser16 → Ala, Ile24 → Thr) compared with the single glucagon isolated from the river lamprey Lampetra fluviatilis. As Petromyzon and Lampetra glucagons differ by six amino acid residues, the data suggest that a duplication of the glucagon gene occurred prior to or early in lamprey evolution. Although both genes are strongly expressed in G. australis, the expression of one gene predominates in P. marinus while that of the other gene predominates in L. fluviatilis. Previous work has shown that, in the islet organ of G. australis, preprosomatostatin is processed almost exclusively to somatostatin=33. However, the present study demonstrates that somatostatin-14 is the major molecular form in G. australis intestine with somatostatin-33 present only as a minor component. This result demonstrates a tissue-dependent pathway of posttranslational processing of p reprosomatostatin in the Geotria enteropancreatic system.
Details
- Title
- Multiple forms of glucagon and somatostatin isolated from the intestine of the Southern-Hemisphere Lamprey Geotria australis
- Authors/Creators
- Y. Wang (Author/Creator) - Creighton UniversityP.F. Nielsen (Author/Creator)J.H. Youson (Author/Creator) - University of TorontoI.C. Potter (Author/Creator) - Murdoch UniversityJ.M. Conlon (Author/Creator) - Creighton University
- Publication Details
- General and Comparative Endocrinology, Vol.113(2), pp.274-282
- Publisher
- Academic Press Inc.
- Identifiers
- 991005544245807891
- Murdoch Affiliation
- School of Biological Sciences and Biotechnology
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
43 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.195 Neuroendocrine & Intestinal Disorders
- 1.195.565 Neuroendocrine Tumors
- Web Of Science research areas
- Endocrinology & Metabolism
- Zoology
- ESI research areas
- Biology & Biochemistry