Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs

R.J.T. Murphy; J.P. Ramsay; Y.T. Lee; S. Pang; M.A. O'Dea; J.C. Pearson; J.E. Axon; E. Raby; S.M. Abdulgader; A. Whitelaw; G.W. Coombs

doi:10.1016/j.ijantimicag.2019.08.022

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Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs

Journal article

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Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs

R.J.T. Murphy, J.P. Ramsay, Y.T. Lee, S. Pang, M.A. O'Dea, J.C. Pearson, J.E. Axon, E. Raby, S.M. Abdulgader, A. Whitelaw, …

International Journal of Antimicrobial Agents, Vol.54(6), pp.681-685

2019

DOI: https://doi.org/10.1016/j.ijantimicag.2019.08.022

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Abstract

Staphylococcus aureus is a serious human and animal pathogen. Multilocus sequence type 612 (ST612) is the dominant methicillin-resistant S. aureus (MRSA) clone in certain South African hospitals and is sporadically isolated from horses and horse-associated veterinarians in Australia. Colonization and infection by ST612-MRSA is increasing in Western Australia. Whole-genome sequencing was performed for 51 ST612-MRSA isolated from Western Australian patients and healthcare workers, South African hospital patients, Australian veterinarians and New South Wales horses. Core-genome phylogenies suggested Australian equine and veterinarian-associated ST612 were monophyletic. Individual Western Australian isolates grouped either with this equine-associated lineage or more diverse lineages related to those in South African hospitals. Bioinformatic analyses of the complete ST612-MRSA reference genome SVH7513 confirmed ST612-MRSA was closely related to ST8 USA500 MRSA. Common use of rifampicin in South Africa and equine veterinarian practice may favor ST612-MRSA in these settings. ST612-MRSA-colonized humans and horses are potential reservoirs for MRSA in Australia.

Details

Title: Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs
Authors/Creators: R.J.T. Murphy (Author/Creator) - Curtin University
J.P. Ramsay (Author/Creator) - Curtin University
Y.T. Lee (Author/Creator) - Murdoch University
S. Pang (Author/Creator) - Murdoch University
M.A. O'Dea (Author/Creator)
J.C. Pearson (Author/Creator) - Fiona Stanley Hospital
J.E. Axon (Author/Creator) - Clovelly Intensive Care Unit, Scone Equine Hospital, 106 Liverpool Street, Scone, New South Wales, Australia
E. Raby (Author/Creator) - Fiona Stanley Hospital
S.M. Abdulgader (Author/Creator) - Stellenbosch University
A. Whitelaw (Author/Creator) - Stellenbosch University
G.W. Coombs (Author/Creator) - Murdoch University
Publication Details: International Journal of Antimicrobial Agents, Vol.54(6), pp.681-685
Publisher: Elsevier
Identifiers: 991005541236007891
Copyright: © 2019 Elsevier B.V.
Murdoch Affiliation: Antimicrobial Resistance and Infectious Disease Laboratory
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.173 MRSA and VRE
Web Of Science research areas: Infectious Diseases; Microbiology; Pharmacology & Pharmacy
ESI research areas: Pharmacology & Toxicology