Journal article
Mutually Exclusive T-Cell Receptor Induction and Differential Susceptibility to Human Immunodeficiency Virus Type 1 Mutational Escape Associated with a Two-Amino-Acid Difference between HLA Class I Subtypes
Journal of Virology, Vol.81(4), pp.1619-1631
2007
Abstract
The relative contributions of HLA alleles and T-cell receptors (TCRs) to the prevention of mutational viral escape are unclear. Here, we examined human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses restricted by two closely related HLA class I alleles, B*5701 and B*5703, that differ by two amino acids but are both associated with a dominant response to the same HIV-1 Gag epitope KF11 (KAFSPEVIPMF). When this epitope is presented by HLA-B*5701, it induces a TCR repertoire that is highly conserved among individuals, cross-recognizes viral epitope variants, and is rarely associated with mutational escape. In contrast, KF11 presented by HLA-B*5703 induces an entirely different, more heterogeneous TCR β-chain repertoire that fails to recognize specific KF11 escape variants which frequently arise in clade C-infected HLA-B*5703+ individuals. These data show the influence of HLA allele subtypes on TCR selection and indicate that extensive TCR diversity is not a prerequisite to prevention of allowable viral mutations.
Details
- Title
- Mutually Exclusive T-Cell Receptor Induction and Differential Susceptibility to Human Immunodeficiency Virus Type 1 Mutational Escape Associated with a Two-Amino-Acid Difference between HLA Class I Subtypes
- Authors/Creators
- X. G. Yu (Author/Creator) - Massachusetts General HospitalM. Lichterfeld (Author/Creator) - Harvard UniversityS. Chetty (Author/Creator) - University of KwaZulu-NatalK.L. Williams (Author/Creator) - Harvard UniversityS.K. Mui (Author/Creator) - Harvard UniversityT. Miura (Author/Creator) - Harvard UniversityN. Frahm (Author/Creator) - Harvard UniversityM.E. Feeney (Author/Creator) - Harvard UniversityY. Tang (Author/Creator) - Harvard UniversityF. Pereyra (Author/Creator) - Harvard UniversityM.X. LaBute (Author/Creator) - Los Alamos National LaboratoryK. Pfafferott (Author/Creator) - Medawar Building for Pathogen ResearchA. Leslie (Author/Creator) - Medawar Building for Pathogen ResearchH. Crawford (Author/Creator) - Medawar Building for Pathogen ResearchR. Allgaier (Author/Creator) - Harvard UniversityW. Hildebrand (Author/Creator) - University of Oklahoma Health Sciences CenterR. Kaslow (Author/Creator) - University of Alabama at BirminghamC. Brander (Author/Creator) - Harvard UniversityT.M. Allen (Author/Creator) - Harvard UniversityE.S. Rosenberg (Author/Creator) - Harvard UniversityP. Kiepiela (Author/Creator) - University of KwaZulu-NatalM. Vajpayee (Author/Creator) - All India Institute of Medical SciencesP.A. Goepfert (Author/Creator) - University of Alabama at BirminghamM. Altfeld (Author/Creator) - Harvard UniversityP.J.R. Goulder (Author/Creator) - Medawar Building for Pathogen ResearchB.D. Walker (Author/Creator) - Howard Hughes Medical Institute
- Publication Details
- Journal of Virology, Vol.81(4), pp.1619-1631
- Publisher
- American Society for Microbiology
- Identifiers
- 991005542695307891
- Copyright
- © American Society for Microbiology
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.46 HIV Pathogenesis
- Web Of Science research areas
- Virology
- ESI research areas
- Microbiology