Mycobacterium chimaera colonisation of heater–cooler units (HCU) in Western Australia, 2015: investigation of possible iatrogenic infection using whole genome sequencing

J.O. Robinson; G.W. Coombs; D.J. Speers; T. Keehner; A.D. Keil; V. D’Abrera; P. Boan; S. Pang

doi:10.2807/1560-7917.ES.2016.21.46.30396

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Mycobacterium chimaera colonisation of heater–cooler units (HCU) in Western Australia, 2015: investigation of possible iatrogenic infection using whole genome sequencing

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Mycobacterium chimaera colonisation of heater–cooler units (HCU) in Western Australia, 2015: investigation of possible iatrogenic infection using whole genome sequencing

J.O. Robinson, G.W. Coombs, D.J. Speers, T. Keehner, A.D. Keil, V. D’Abrera, P. Boan and S. Pang

Eurosurveillance, Vol.21(46)

2016

DOI: https://doi.org/10.2807/1560-7917.ES.2016.21.46.30396

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Abstract

Following the reported link between heater–cooler unit (HCU) colonisation with Mycobacterium chimaera and endocarditis, mycobacterial sampling of all HCUs in use in Western Australia was initiated from August 2015, revealing M. chimaera colonisation in 10 of 15 HCUs. After M. chimaera was isolated from a pleural biopsy from a cardiothoracic patient who may have been exposed to a colonised HCU, a whole genome sequencing investigation was performed involving 65 specimens from 15 HCUs across five hospitals to assess if this infection was related to the HCU. Genetic relatedness was found between the 10 HCU M. chimaera isolates from four hospitals. However the M. chimaera isolate from the cardiothoracic patient was not genetically related to the HCU M. chimaera isolates from that hospital, nor to the other HCU isolates, indicating that the HCUs were not the source of the infection in this patient.

Details

Title: Mycobacterium chimaera colonisation of heater–cooler units (HCU) in Western Australia, 2015: investigation of possible iatrogenic infection using whole genome sequencing
Authors/Creators: J.O. Robinson (Author/Creator) - Royal Perth Hospital
G.W. Coombs (Author/Creator) - Fiona Stanley Hospital
D.J. Speers (Author/Creator) - The University of Western Australia
T. Keehner (Author/Creator) - Pathwest Laboratory Medicine
A.D. Keil (Author/Creator) - Pathwest Laboratory Medicine
V. D’Abrera (Author/Creator) - St John of God Health Care
P. Boan (Author/Creator) - Fiona Stanley Hospital
S. Pang (Author/Creator) - Fiona Stanley Hospital
Publication Details: Eurosurveillance, Vol.21(46)
Publisher: European Centre for Disease Prevention and Control (ECDC)
Identifiers: 991005544182907891
Copyright: © 2016, European Centre for Disease Prevention and Control (ECDC).
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.194 Tuberculosis & Leprosy; 1.194.273 TB Diagnostics & Treatment
Web Of Science research areas: Infectious Diseases
ESI research areas: Immunology