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Published (Version of Record)CC BY-NC-ND V4.0, Open Access
Journal article
Mycoplasma and Ureaplasma donor derived infection and hyperammonemia syndrome in four solid organ transplant recipients from a single donor
Open forum infectious diseases, Vol.10(6), ofad263
2023
Abstract
Hyperammonemia syndrome (HS) is a life-threatening condition occurring in solid organ transplant patients, affecting primarily lung recipients, and is associated with Mycoplasma hominis and/or Ureaplasma spp infection. The organ donor was a young man who died of hypoxic brain injury and had urethral discharge antemortem. The donor and 4 solid organ transplant recipients had infection with M hominis and/or Ureaplasma spp. The lung and heart recipients both developed altered conscious state and HS associated with M hominis and Ureaplasma spp infections. Despite treatment with antibiotics and ammonia scavengers, both the lung and heart recipients died at day +102 and day +254, respectively. After diagnosis in the thoracic recipients, screening samples from the liver recipient and 1 kidney recipient were culture positive for M hominis with or without Ureaplasma spp. Neither the liver nor kidney recipients developed HS. Our case series demonstrates the unique finding of M hominis and Ureaplasma spp dissemination from an immunocompetent donor across 4 different organ recipients. Phylogenetic whole genome sequencing analysis demonstrated that M hominis samples from recipients and donor were closely related, suggesting donor-derived infection. Screening of lung donors and/or recipients for Mycoplasma and Ureaplasma spp is recommended, as well as prompt treatment with antimicrobials to prevent morbidity.
Details
- Title
- Mycoplasma and Ureaplasma donor derived infection and hyperammonemia syndrome in four solid organ transplant recipients from a single donor
- Authors/Creators
- Charlotte Wigston - Fiona Stanley HospitalMelanie Lavender - Fiona Stanley HospitalRebecca Long - Fiona Stanley HospitalDipen Sankhesara - Fiona Stanley HospitalDavid Ching - Fiona Stanley HospitalGraham Weaire-Buchanan - Fiona Stanley HospitalShakeel Mowlaboccus - Murdoch UniversityGeoffrey W Coombs - Murdoch UniversityKaitlyn Lam - Fiona Stanley HospitalJeremy Wrobel - Fiona Stanley HospitalMeow Cheong Yaw - Fiona Stanley HospitalMichael Musk - Fiona Stanley HospitalPeter Boan - Fiona Stanley Hospital
- Publication Details
- Open forum infectious diseases, Vol.10(6), ofad263
- Publisher
- Oxford University Press
- Identifiers
- 991005579455907891
- Copyright
- © The Author(s) 2023
- Murdoch Affiliation
- Centre for Biosecurity and One Health
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.248 Sexually Transmitted Infections
- 1.248.1317 Mycoplasma Infections
- Web Of Science research areas
- Immunology
- Infectious Diseases
- Microbiology
- ESI research areas
- Immunology