Myelin oligodendrocyte glycoprotein antibody-associated disorders coexisting with ankylosing spondylitis: Potential association between demyelination and tumor necrosis factor inhibitors

W. Luo; R. Li; Y. Chang; H. She; A.G. Kermode; W. Qiu

doi:10.1016/j.msard.2021.102889

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Myelin oligodendrocyte glycoprotein antibody-associated disorders coexisting with ankylosing spondylitis: Potential association between demyelination and tumor necrosis factor inhibitors

Journal article

Peer reviewed

Myelin oligodendrocyte glycoprotein antibody-associated disorders coexisting with ankylosing spondylitis: Potential association between demyelination and tumor necrosis factor inhibitors

W. Luo, R. Li, Y. Chang, H. She, A.G. Kermode and W. Qiu

Multiple Sclerosis and Related Disorders, Vol.51, Art. 102889

2021

DOI: https://doi.org/10.1016/j.msard.2021.102889

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Abstract

Myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) is a newly described demyelinating disease. Ankylosing spondylitis (AS) is an inflammatory disease that predominantly affects the axial skeleton. Treatments for AS, such as tumor necrosis factor alpha (TNFα) inhibitors, may induce demyelination. We report the first case of MOGAD coexisting with AS and postulate a potential association with TNFα inhibitors. Further studies are needed to clarify the risk of demyelinating events following anti-TNFα therapy and to elucidate the relationship between MOGAD and AS.

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Title: Myelin oligodendrocyte glycoprotein antibody-associated disorders coexisting with ankylosing spondylitis: Potential association between demyelination and tumor necrosis factor inhibitors
Authors/Creators: W. Luo (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
R. Li (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
Y. Chang (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
H. She (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
A.G. Kermode (Author/Creator) - Sun Yat-sen University
W. Qiu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
Publication Details: Multiple Sclerosis and Related Disorders, Vol.51, Art. 102889
Publisher: Elsevier B.V.
Identifiers: 991005543614007891
Copyright: © 2021 Elsevier B.V.
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.203 Neuromuscular Disorders; 1.203.147 Multiple Sclerosis
Web Of Science research areas: Clinical Neurology
ESI research areas: Neuroscience & Behavior