Myg1-deficient mice display alterations in stress-induced responses and reduction of sex-dependent behavioural differences

M-A Philips; U. Abramov; K. Lilleväli; H. Luuk; K. Kurrikoff; S. Raud; M. Plaas; J. Innos; T. Puussaar; S. Kõks

doi:10.1016/j.bbr.2009.10.005

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Myg1-deficient mice display alterations in stress-induced responses and reduction of sex-dependent behavioural differences

Journal article

Peer reviewed

Myg1-deficient mice display alterations in stress-induced responses and reduction of sex-dependent behavioural differences

M-A Philips, U. Abramov, K. Lilleväli, H. Luuk, K. Kurrikoff, S. Raud, M. Plaas, J. Innos, T. Puussaar and S. Kõks

Behavioural Brain Research, Vol.207(1), pp.182-195

2010

DOI: https://doi.org/10.1016/j.bbr.2009.10.005

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Abstract

Myg1 (Melanocyte proliferating gene 1) is a highly conserved and ubiquitously expressed gene, which encodes a protein with mitochondrial and nuclear localization. In the current study we demonstrate a gradual decline of Myg1 expression during the postnatal development of the mouse brain that suggests relevance for Myg1 in developmental processes. To study the effects of Myg1 loss-of-function, we created Myg1-deficient (−/−) mice by displacing the entire coding sequence of the gene. Initial phenotyping, covering a multitude of behavioural, cognitive, neurological, physiological and stress-related responses, revealed that homozygous Myg1 (−/−) mice are vital, fertile and display no gross abnormalities. Myg1 (−/−) mice showed an inconsistent pattern of altered anxiety-like behaviour in different tests. The plus-maze and social interaction tests revealed that male Myg1 (−/−) mice were significantly less anxious than their wild-type littermates; female (−/−) mice showed increased anxiety in the locomotor activity arena. Restraint-stress significantly reduced the expression of the Myg1 gene in the prefrontal cortex of female wild-type mice and restrained female (−/−) mice showed a blunted corticosterone response, suggesting involvement of Myg1 in stress-induced responses. The main finding of the present study was that Myg1 invalidation decreases several behavioural differences between male and female animals that were obvious in wild-type mice, indicating that Myg1 contributes to the expression of sex-dependent behavioural differences in mice. Taken together, we provide evidence for the involvement of Myg1 in anxiety- and stress-related responses and suggest that Myg1 contributes to the expression of sex-dependent behavioural differences.

Details

Title: Myg1-deficient mice display alterations in stress-induced responses and reduction of sex-dependent behavioural differences
Authors/Creators: M-A Philips (Author/Creator)
U. Abramov (Author/Creator)
K. Lilleväli (Author/Creator)
H. Luuk (Author/Creator)
K. Kurrikoff (Author/Creator)
S. Raud (Author/Creator)
M. Plaas (Author/Creator)
J. Innos (Author/Creator)
T. Puussaar (Author/Creator)
S. Kõks (Author/Creator)
Publication Details: Behavioural Brain Research, Vol.207(1), pp.182-195
Publisher: Elsevier B.V.
Identifiers: 991005544780807891
Copyright: © 2009 Elsevier B.V.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.5 Neuroscience; 1.5.1511 Rodent Behavior
Web Of Science research areas: Behavioral Sciences; Neurosciences
ESI research areas: Neuroscience & Behavior