Journal article
Myostatin and its implications on animal breeding: a review
Animal Genetics, Vol.36(1), pp.1-6
2005
Abstract
Myostatin, or growth and differentiation factor 8 (GDF8), has been identified as the factor causing a phenotype known as double muscling, in which a series of mutations render the gene inactive, and therefore, unable to regulate muscle fibre deposition. This phenotype occurs at a high frequency in some breeds of cattle such as Belgian Blue and Peidmontese. Phylogenetic analysis has shown that there has been positive selection pressure for non-synonymous mutations within the myostatin gene family, around the time of the divergence of cattle, sheep and goats, and these positive selective pressures on non-ancestral myostatin are relatively recent. To date, there have been reports of nine mutations in coding regions of myostatin that cause non-synonymous changes, of which three cause missense mutations. including two in exon 1 and one in exon 2. The remaining six mutations, located in exons 2 and 3, result in premature stop codons, which are the mutations responsible for the double-muscling phenotype. Unfortunately, breed management problems exist for double-muscled cattle, such as birthing difficulties, which can be overcome through genetically controlled breeding programmes, as shown in this review.
Details
- Title
- Myostatin and its implications on animal breeding: a review
- Authors/Creators
- R.H.S. Bellinge (Author/Creator) - Murdoch UniversityD.A. Liberles (Author/Creator) - University of BergenS.P.A. Iaschi (Author/Creator) - The University of Western AustraliaP.A. O'Brien (Author/Creator)G.K. Tay (Author/Creator) - Murdoch University
- Publication Details
- Animal Genetics, Vol.36(1), pp.1-6
- Publisher
- Blackwell Publishing Inc.
- Identifiers
- 991005543362607891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.255 Musculoskeletal Disorders
- 1.255.1761 Muscle Wasting
- Web Of Science research areas
- Agriculture, Dairy & Animal Science
- Genetics & Heredity
- ESI research areas
- Plant & Animal Science