Journal article
NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: An Eleven-Year follow-up study
The American Journal of Gastroenterology, Vol.104(4), pp.861-867
2009
Abstract
OBJECTIVES:
Non-alcoholic fatty liver disease (NAFLD) uncommonly results in cirrhosis and liver-related death; however, its impact on the development of metabolic complications remains unclear. We sought to determine whether NAFLD with elevated aminotransaminase (ALT) levels was a risk factor for incident diabetes or the metabolic syndrome (MS) over an 11-year period.
METHODS:
Adult residents of Busselton, Western Australia underwent assessment in 1994-1995 as part of the Busselton Health Survey. NAFLD was diagnosed on the basis of a raised ALT (>40 IU/l) after the exclusion of alcohol, viral, metabolic, and autoimmune liver disease. NAFLD and non-NAFLD subjects were reassessed in 2005 for liver complications, diabetes, and the MS.
RESULTS:
A total of 358 subjects, 68% male (109 NAFLD, 249 non-NAFLD), mean age (s.d.) 59.9 (11.6) years, attended follow-up 11.1 years after the initial assessment. After excluding subjects with diabetes at baseline, those with NAFLD were more likely to have developed diabetes on follow-up (20/106, 18.9% vs. 15/246, 6.1%; P<0.001). After excluding subjects with MS at baseline, those with NAFLD were more likely to have developed MS at follow-up (27/81, 33.3% vs. 51/226, 22.6%; P=0.056). However, in multivariate logistic regression models, NAFLD was no longer a significant independent predictor of the development of diabetes or MS after adjusting for baseline waist circumference, hypertension, and insulin resistance. None of the subjects developed liver complications.
CONCLUSIONS:
Subjects with NAFLD and elevated ALT levels are at an increased risk of developing diabetes and the MS. This may be because of the presence of associated metabolic risk factors.
Details
- Title
- NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: An Eleven-Year follow-up study
- Authors/Creators
- L.A. Adams (Author/Creator)O.R. Waters (Author/Creator)M.W. Knuiman (Author/Creator)R.R. Elliott (Author/Creator)J.K. Olynyk (Author/Creator)
- Publication Details
- The American Journal of Gastroenterology, Vol.104(4), pp.861-867
- Publisher
- Nature Publishing Group
- Identifiers
- 991005544595507891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
80 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.125 Hepatitis
- 1.125.663 NAFLD
- Web Of Science research areas
- Gastroenterology & Hepatology
- ESI research areas
- Clinical Medicine