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Journal article
NEARER SCAN (LENO BESIK) evaluation of a task-sharing echocardiographic active case finding programme for rheumatic heart disease in Australia and Timor-Leste: protocol for a hybrid type II effectiveness-implementation study
BMJ open, Vol.14(10), 083467
2024
PMID: 39424380
Abstract
Introduction Rheumatic heart disease (RHD) is underdiagnosed globally resulting in missed treatment opportunities and adverse clinical outcomes. We describe the protocol for a study which aims to co-design, implement and conduct an evaluation of a task-sharing approach to echocardiographic active case finding for early detection and management of RHD in high-risk settings in Australia and Timor-Leste.Methods and analysis Echocardiograms will be obtained by trained local staff using hand-held echocardiographic devices employing the 'Single Parasternal Long Axis view with a Sweep of the Heart' (SPLASH) technique and interpreted by experts remote from the site of acquisition. Approximately 1500 children and pregnant women will be screened across high-risk communities in Australia and Timor-Leste over an 18-month period. The study will use a type II effectiveness-implementation hybrid design. A tailored package of implementation strategies will be co-designed with communities and health services and mapped onto a Theory of Change framework. The clinical effectiveness will be assessed as the change in the proportion of the target population that are prescribed secondary prophylaxis for RHD by the end of the study compared with baseline. The implementation will be assessed as the adoption, penetration, sustainability, fidelity and cost of the programme with a mixed-methods theory-based and economic evaluation. Data will include numbers of normal, abnormal and uninterpretable SPLASH echocardiograms obtained, numbers of participants progressing through the cascade of care, interviews with staff and programme costs.Ethics and dissemination Ethical approval has been obtained from the Human Research Ethics Committee of the NT Department of Health and Menzies School of Health Research, Darwin (HREC-2022-4479), the Western Australian Aboriginal Health Ethics Committee (HREC-1237) and the Instituto Nasional Saude Publika Timor-Leste Ethics and Technical Committee (03-UEPD/INSP-TL/V/2023). Informed consent is required to be enrolled. Study findings will be disseminated in the communities involved and submitted for publication.Trial registration number NCT06002243.
Details
- Title
- NEARER SCAN (LENO BESIK) evaluation of a task-sharing echocardiographic active case finding programme for rheumatic heart disease in Australia and Timor-Leste: protocol for a hybrid type II effectiveness-implementation study
- Authors/Creators
- Benjamin Jones - Charles Darwin UniversityJames Marangou - Charles Darwin UniversityJennifer Yan - Charles Darwin UniversityAnna Ralph - Charles Darwin UniversityAlice Mitchell - Menzies School of Health ResearchAlex Kaethner - Charles Darwin UniversityBo Remenyi - Charles Darwin UniversityVicki Wade - National Heart Foundation of AustraliaJudith M. Katzenellenbogen - The University of Western AustraliaAnferida Fernandes Monteiro - Charles Darwin UniversityJeffrey W. Cannon - The Kids Research Institute AustraliaNatasha J. Howard - South Australian Health and Medical Research InstituteMarisa Gilles - WA Country Health ServiceEmma Haynes - The University of Western AustraliaHerculano Seixas - Hosp Nacl Guido Valadares, Dili, Timor-LesteJoaquina Maurays - Universidade da PazJade Neave - Charles Darwin UniversityChantelle Pears - WA Country Health ServiceDaniel Engelman - Murdoch Children's Research InstituteAndrew Steer - The Royal Melbourne HospitalKarla Canuto - Flinders UniversityHolger Unger - Charles Darwin UniversityMeghan Bailey - Charles Darwin UniversityMaria Tanesi - Charles Darwin UniversitySalvador Amaral - Charles Darwin UniversityHelder Neto - National University of East TimorMaida Stewart - Northern Territory Health ServicesPaul Burgess - Government of the Northern TerritoryAlex Brown - Australian National UniversityBart J. Currie - Royal Darwin HospitalGraham Hillis - The University of Western AustraliaPeter Morris - Charles Darwin UniversityDavid Simon - Katherine HospitalGavin Wheaton - Women's and Children's HospitalJacqui Williamson - Charles Darwin UniversityJessica de Dassel - Charles Darwin UniversitySimon Slota-Kan - WA Country Health ServiceJonathan Carapetis - The Kids Research Institute AustraliaMike English - University of OxfordShobhana Nagraj - University of CambridgeJoshua R. Francis - Charles Darwin University
- Publication Details
- BMJ open, Vol.14(10), 083467
- Publisher
- Bmj Publishing Group
- Number of pages
- 11
- Grant note
- Rhodes Trust GNT2005316 / NHMRC PhD Scholarship; National Health & Medical Research Council (NHMRC) of Australia 207522 / Wellcome Senior Fellowship; Wellcome Trust GNT2015869 / Australian Medical Research Futures Fund Cardiovascular Health Mission GNT1194707 / National Health and Medical Research Council (NHMRC) Investigator Grant; National Health & Medical Research Council (NHMRC) of Australia East Timor Hearts Fund
- Identifiers
- 991005884837107891
- Copyright
- © Author(s) (or their employer(s)) 2024
- Murdoch Affiliation
- Ngangk Yira Institute for Change
- Language
- English
- Resource Type
- Journal article
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