Nano‐Octahedron Cobalt Oxide Decorated Graphene Nanocomposites for the Selective/Simultaneous Detection of Dopamine

Swathi Tharani Dharmalingam; Mushtaq Ahmad Dar; Rukhsana Gul; Manickam Minakshi Sundaram; Ibrahim Abdullah Alnaser; R. Sivasubramanian

doi:10.1002/admi.202400981

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Nano‐Octahedron Cobalt Oxide Decorated Graphene Nanocomposites for the Selective/Simultaneous Detection of Dopamine

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Nano‐Octahedron Cobalt Oxide Decorated Graphene Nanocomposites for the Selective/Simultaneous Detection of Dopamine

Swathi Tharani Dharmalingam, Mushtaq Ahmad Dar, Rukhsana Gul, Manickam Minakshi Sundaram, Ibrahim Abdullah Alnaser and R. Sivasubramanian

Advanced materials interfaces, Vol.12(13), 2400981

2025

DOI: https://doi.org/10.1002/admi.202400981

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Abstract

Co3O4

dopamine

DPV

graphene

uric acid

Nano‐octahedron cobalt oxide decorated graphene nanocomposite is reported in this work for selective and simultaneous determination of dopamine (DA) and uric acid (UA). The composite is synthesized using a hydrothermal method and characterized to identify the crystal structure and its shapes. The Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM) images indicate the silhouette image of the nanocube decorated over graphene oxide. The Gr‐Co₃O₄/glassy carbon electrode (GCE) is utilized for the electrochemical detection of dopamine (DA). Cyclic voltammetry (CV) studies revealed a significant breakthrough such as Gr‐Co₃O₄/GCE exhibited higher electrocatalytic activity for DA oxidation than the bare GCE. Differential pulse voltammetry (DPV) measurements demonstrated a detection limit of 0.09 µM for DA, with a linear response range from 1 to 500 µM. For uric acid (UA), the detection limit and linear range are estimated as 0.2 and 100 to 8000 µM, respectively. The sensor selectively detects DA in the presence of UA is confirmed, with a peak separation of 250 mV between DA and UA. The reliability of the sensor is validated through using human serum specimens, paving the way for exciting potential applications in biomedical research and clinical diagnostics.

Details

Title: Nano‐Octahedron Cobalt Oxide Decorated Graphene Nanocomposites for the Selective/Simultaneous Detection of Dopamine
Authors/Creators: Swathi Tharani Dharmalingam - PSG Institute of Advanced Studies
Mushtaq Ahmad Dar - King Saud University
Rukhsana Gul - King Saud University
Manickam Minakshi Sundaram - Murdoch University
Ibrahim Abdullah Alnaser - King Saud University
R. Sivasubramanian - Amrita Vishwa Vidyapeetham
Publication Details: Advanced materials interfaces, Vol.12(13), 2400981
Publisher: Wiley-VCH GmbH
Number of pages: 10
Grant note: UGC-DAE-CSR: UGC-DAE-CSR, CRS/2023-24/04/1306, RSPD2025R1045 King Saud University, Riyadh, Saudi Arabia
S.T.D. and M.A.D. contributed equally to this work. The authors acknowledge the financial support provided by the UGC-DAE-CSR (CRS/2023-24/04/1306) India. This project was funded by Researchers Supporting Project number (RSPD2025R1045), King Saud University, Riyadh, Saudi Arabia.
Identifiers: 991005753815807891
Murdoch Affiliation: Murdoch University; Centre for Water, Energy and Waste
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 2 Chemistry; 2.145 Biosensors; 2.145.177 Nanomaterial Sensors
Web Of Science research areas: Chemistry, Multidisciplinary; Materials Science, Multidisciplinary
ESI research areas: Materials Science