Narrowband UVB phototherapy for clinically isolated syndrome: A trial to deliver the benefits of Vitamin D and other UVB-Induced molecules

P.H. Hart; R.M. Lucas; D.R. Booth; W.M. Carroll; D. Nolan; J.M. Cole; A.P. Jones; A.G. Kermode

doi:10.3389/fimmu.2017.00003

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Narrowband UVB phototherapy for clinically isolated syndrome: A trial to deliver the benefits of Vitamin D and other UVB-Induced molecules

Journal article

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Peer reviewed

Narrowband UVB phototherapy for clinically isolated syndrome: A trial to deliver the benefits of Vitamin D and other UVB-Induced molecules

P.H. Hart, R.M. Lucas, D.R. Booth, W.M. Carroll, D. Nolan, J.M. Cole, A.P. Jones and A.G. Kermode

Frontiers in Immunology, Vol.8

2017

DOI: https://doi.org/10.3389/fimmu.2017.00003

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Abstract

Low vitamin D and insufficient sun exposure are additive independent risk factors for the development of multiple sclerosis (MS). The usual measure of vitamin D status, serum 25-hydroxy vitamin D [25(OH)D], is also a marker of recent exposure to the UVB rays of sunshine. The main evidence for a protective effect for MS development of higher 25(OH)D comes from observational studies, but this study design cannot separate out whether 25(OH)D is acting as a marker of vitamin D status, sun exposure, or both. In light of a lack of definitive outcomes in MS patients after trials of vitamin D supplementation and the ability of narrowband UVB to induce vitamin D, as well as other immune-regulatory molecules in skin, the Phototherapy for Clinically Isolated Syndrome (PhoCIS) trial was established to investigate the benefits of narrowband UVB, in addition to supplemented vitamin D, on MS development in individuals with Clinically Isolated Syndrome. We propose that the PhoCIS trial provides a fresh approach to re-defining the reported associations of 25(OH)D levels with MS development and progression.

Details

Title: Narrowband UVB phototherapy for clinically isolated syndrome: A trial to deliver the benefits of Vitamin D and other UVB-Induced molecules
Authors/Creators: P.H. Hart (Author/Creator) - The Kids Research Institute Australia
R.M. Lucas (Author/Creator) - Australian National University
D.R. Booth (Author/Creator) - Westmead Institute for Medical Research
W.M. Carroll (Author/Creator) - Sir Charles Gairdner Hospital
D. Nolan (Author/Creator) - Murdoch University
J.M. Cole (Author/Creator) - St John of God Hospital
A.P. Jones (Author/Creator) - The Kids Research Institute Australia
A.G. Kermode (Author/Creator) - Sir Charles Gairdner Hospital
Publication Details: Frontiers in Immunology, Vol.8
Publisher: Frontiers Media
Identifiers: 991005540828907891
Copyright: © 2017 Hart, Lucas, Booth, Carroll, Nolan, Cole, Jones and Kermode.
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.80 Bone Diseases; 1.80.279 Vitamin D
Web Of Science research areas: Immunology
ESI research areas: Immunology