Journal article
Nephrotic syndrome and collagenizing glomerulopathy in PVG/c rats treated with the α-mannosidase inhibitor "swainsonine"
Veterinary Pathology, Vol.20(6), pp.727-736
1983
Abstract
Weanling PVG/c rats treated with the α-mannosidase inhibitor swainsonine developed increasing proteinuria which terminated as a severe nephrotic syndrome after 35 to 45 days. This was associated with a glomerulopathy characterized by the production of collagen fibrils adjacent to endothelial and mesangial cells, foot process expansion, subepithelial projections of the basement membrane, and splitting of the lamina densa. The swainsonine-induced glomerulopathy appeared to be an exacerbation of a spontaneous abnormality in this strain of rat.
Details
- Title
- Nephrotic syndrome and collagenizing glomerulopathy in PVG/c rats treated with the α-mannosidase inhibitor "swainsonine"
- Authors/Creators
- C.R. Huxtable (Author/Creator)P.R. Dorling (Author/Creator)
- Publication Details
- Veterinary Pathology, Vol.20(6), pp.727-736
- Publisher
- SAGE Publications Ltd
- Identifiers
- 991005540700607891
- Copyright
- © 1983, American College of Veterinary Pathologists.
- Murdoch Affiliation
- School of Veterinary Studies
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.55 Urology & Nephrology - General
- 1.55.820 Nephrotic Syndrome
- Web Of Science research areas
- Pathology
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science