Journal article
Neurocognitive outcomes in young adults with early-onset type 1 diabetes: A prospective follow-up study.
Diabetes Care, Vol.34(10), pp.2192-2197
2011
Abstract
OBJECTIVE:
The aim of this study was to reexamine the neurocognitive function of a cohort of young adults with early-onset type 1 diabetes and compare their cognitive function to a matched control group. We also examined whether cognitive function was related to prospectively obtained severe hypoglycemia history, long-term glycemic control, or severe diabetic ketoacidosis.
RESEARCH DESIGN AND METHODS:
Testing included Wechsler Intelligence Scale for Children and Adults, Wechsler Memory Scale, Cattell Culture Fair Intelligence Test (CCFIT), Wisconsin Card Sorting Test (WCST), youth and adult self-report, and Beck Depression Inventory. We tested 34 control subjects (mean ± SE, age 19.5 ± 0.5 years) and 33 type 1 diabetic subjects (age 19.3 ± 0.5 years, age at type 1 diabetes onset 3.3 ± 0.3 years, A1C from diagnosis 8.7 ± 0.1%, and diabetes duration 16.0 ± 0.5 years).
RESULTS:
There was no difference in full-scale IQ scores in type 1 diabetic and control Subjects (100.7 ± 2.0 vs. 102.5 ± 1.4). There was no difference between groups in memory subtests or in reporting of emotional and behavioral difficulties. The type 1 diabetes group scored lower on the CCFIT for fluid intelligence compared with control subjects (P = 0.028) and also scored lower on WCST with more perseverative errors (P = 0.002) and fewer categories completed (P = 0.022).
CONCLUSIONS:
These data suggest no difference in general intellectual ability, memory, and emotional difficulties in our cohort of young adults with early-onset type 1 diabetes compared with control subjects and no deterioration over time. There were, however, findings to suggest subtle changes leading to poorer performance on complex tasks of executive function.
Details
- Title
- Neurocognitive outcomes in young adults with early-onset type 1 diabetes: A prospective follow-up study.
- Authors/Creators
- T.T. Ly (Author/Creator)M. Anderson (Author/Creator)K.A. McNamara (Author/Creator)E.A. Davis (Author/Creator)T.W. Jones (Author/Creator)
- Publication Details
- Diabetes Care, Vol.34(10), pp.2192-2197
- Publisher
- American Diabetes Association
- Number of pages
- 6
- Identifiers
- 991005541166907891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
- Publisher URL
- http://www.diabetes.org/
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
125 File views/ downloads
52 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.26 Diabetes
- 1.26.42 Diabetes Management
- Web Of Science research areas
- Endocrinology & Metabolism
- ESI research areas
- Clinical Medicine