Journal article
Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice
Science Translational Medicine, Vol.11(518)
2019
Abstract
The gut microbiota evolves as the host ages, yet the effects of these microbial changes on host physiology and energy homeostasis are poorly understood. To investigate these potential effects, we transplanted the gut microbiota of old or young mice into young germ-free recipient mice. Both groups showed similar weight gain and skeletal muscle mass, but germ-free mice receiving a gut microbiota transplant from old donor mice unexpectedly showed increased neurogenesis in the hippocampus of the brain and increased intestinal growth. Metagenomic analysis revealed age-sensitive enrichment in butyrate-producing microbes in young germ-free mice transplanted with the gut microbiota of old donor mice. The higher concentration of gut microbiota–derived butyrate in these young transplanted mice was associated with an increase in the pleiotropic and prolongevity hormone fibroblast growth factor 21 (FGF21). An increase in FGF21 correlated with increased AMPK and SIRT-1 activation and reduced mTOR signaling. Young germ-free mice treated with exogenous sodium butyrate recapitulated the prolongevity phenotype observed in young germ-free mice receiving a gut microbiota transplant from old donor mice. These results suggest that gut microbiota transplants from aged hosts conferred beneficial effects in responsive young recipients.
Details
- Title
- Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice
- Authors/Creators
- P. Kundu (Author/Creator) - Nanyang Technological UniversityH.U. Lee (Author/Creator) - Nanyang Technological UniversityI. Garcia-Perez (Author/Creator) - Imperial College LondonE.X.Y. Tay (Author/Creator) - National University of SingaporeH. Kim (Author/Creator) - Nanyang Technological UniversityL.E. Faylon (Author/Creator) - Singapore Centre for Environmental Life Sciences EngineeringK.A. Martin (Author/Creator) - Nanyang Technological UniversityR. Purbojati (Author/Creator) - Singapore Centre for Environmental Life Sciences EngineeringD.I. Drautz-Moses (Author/Creator) - Singapore Centre for Environmental Life Sciences EngineeringS. Ghosh (Author/Creator) - Duke-NUS Medical SchoolJ.K. Nicholson (Author/Creator) - Murdoch UniversityS. Schuster (Author/Creator) - Singapore Centre for Environmental Life Sciences EngineeringE. Holmes (Author/Creator) - UK Dementia Research InstituteS. Pettersson (Author/Creator) - Karolinska Institutet
- Publication Details
- Science Translational Medicine, Vol.11(518)
- Publisher
- AAAS
- Identifiers
- 991005539593907891
- Copyright
- © 2019 American Association for the Advancement of Science
- Murdoch Affiliation
- Australian National Phenome Centre
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.384 Gut Microbiota
- Web Of Science research areas
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- Medicine, Research & Experimental
- ESI research areas
- Biology & Biochemistry