Journal article
Neuromodulation by paired-pulse TMS at an I-wave interval facilitates multiple I-waves
Experimental Brain Research, Vol.193(1), pp.1-7
2009
Abstract
Corticospinal excitability can be increased by a transcranial magnetic stimulation (TMS) intervention that delivers repeated paired TMS pulses at an I (indirect)-wave interval of 1.5 ms. This is thought to target excitatory synaptic events by reinforcing facilitatory I-wave interaction, however, it remains to be determined what effect this intervention has on the various I-wave components. In the present study we compared I-wave facilitation curves over a range of inter-pulse intervals (IPIs) encompassing the first three I-waves, before and after 15 min of a paired-pulse TMS intervention with an IPI of 1.5 ms. The three peaks in the I-wave facilitation curves occurred at the same IPIs pre- and post-intervention (1.3, 2.5 and 4.3 ms). The facilitation curves were increased in amplitude for all three I-wave peaks post-intervention (mean increase 33%), and the mean increase across all IPIs correlated with the post-intervention increase in single-pulse MEP amplitude (r = 0.77). Modelling showed that the changes in the post-intervention curves were consistent with an increase in amplitude and broadening of the individual I-wave peaks. We conclude that an iTMS intervention with an IPI of 1.5 ms is able to target multiple I-waves. The findings are consistent with existing models of I-wave generation and suggest that the intervention increases the efficacy of synaptic events associated with the generation of descending I-wave volleys.
Details
- Title
- Neuromodulation by paired-pulse TMS at an I-wave interval facilitates multiple I-waves
- Authors/Creators
- R.F.H. Cash (Author/Creator) - The University of Western AustraliaN.M. Benwell (Author/Creator) - The University of Western AustraliaK. Murray (Author/Creator) - The University of Western AustraliaF.L. Mastaglia (Author/Creator) - The University of Western AustraliaG.W. Thickbroom (Author/Creator) - The University of Western Australia
- Publication Details
- Experimental Brain Research, Vol.193(1), pp.1-7
- Publisher
- Springer-Verlag Berlin Heidelberg
- Identifiers
- 991005542312407891
- Copyright
- 2008 Springer-Verlag
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.811 Transcranial Magnetic Stimulation
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior