Journal article
Neuropeptide Y expression in phaeochromocytomas: relative absence in tumours from patients with von Hippel-Lindau syndrome
Journal of Endocrinology, Vol.193(2), pp.225-233
05/2007
Abstract
Phaeochromocytomas are rare neuroendocrine tumours that produce catecholamines and numerous secretory proteins and peptides, including neuropeptide Y (NPY), a vasoactive peptide with influences on blood pressure. The production of catecholamines and NPY by phaeochromocytomas is highly variable. This study examined influences of hereditary factors and differences in catecholamine production on tumour expression of NPY, as assessed by quantitative PCR, enzyme immunoassay and immunohistochemistry. Phaeochromocytomas included hereditary adrenaline-producing tumours (adrenergic phenotype) in multiple endocrine neoplasia type 2 (MEN 2), predominantly noradrenaline-producing tumours (noradrenergic phenotype) in von Hippel-Lindau (VHL) syndrome, and other adrenergic and noradrenergic tumours where there was no clear hereditary syndrome. NPY levels in phaeochromocytomas from VHL patients were lower (P<0.0001) than in those from MEN 2 patients for both mRNA (84-fold difference) and the peptide (99-fold difference). These findings were supported by immunohistochemistry. NPY levels were also lower in VHL tumours than in those where there was no hereditary syndrome. Relative absence of expression of NPY in phaeochromocytomas from VHL patients when compared with other groups appears to be largely independent of differences in catecholamine production and is consistent with a unique phenotype in VHL syndrome.
Details
- Title
- Neuropeptide Y expression in phaeochromocytomas: relative absence in tumours from patients with von Hippel-Lindau syndrome
- Authors/Creators
- S. Cleary (Author/Creator)J.K. Phillips (Author/Creator)T.T. Huynh (Author/Creator)K. Pacak (Author/Creator)A.G. Elkahloun (Author/Creator)J. Barb (Author/Creator)R.A. Worrell (Author/Creator)D.S. Goldstein (Author/Creator)G. Eisenhofer (Author/Creator)
- Publication Details
- Journal of Endocrinology, Vol.193(2), pp.225-233
- Publisher
- Society for Endocrinology
- Identifiers
- 991005545221207891
- Copyright
- © 2007 Society for Endocrinology.
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
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- Citation topics
- 1 Clinical & Life Sciences
- 1.278 Adrenal Disorders
- 1.278.802 Adrenal Tumors
- Web Of Science research areas
- Endocrinology & Metabolism
- ESI research areas
- Biology & Biochemistry