Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation

S. Rainey-Smith; L-W Schroetke; P. Bahia; A. Fahmi; R. Skilton; J.P.E. Spencer; C. Rice-Evans; M. Rattray; R.J. Williams

doi:10.1016/j.neulet.2008.04.056

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Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation

Journal article

Peer reviewed

Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation

S. Rainey-Smith, L-W Schroetke, P. Bahia, A. Fahmi, R. Skilton, J.P.E. Spencer, C. Rice-Evans, M. Rattray and R.J. Williams

Neuroscience Letters, Vol.438(1), pp.29-33

2008

DOI: https://doi.org/10.1016/j.neulet.2008.04.056

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Abstract

Dietary flavonoids, including the citrus flavanone hesperetin, may have stimulatory effects on cytoprotective intracellular signalling pathways. In primary mouse cortical neurone cultures, but not SH-SY5Y human neuroblastoma cells or human primary dermal fibroblasts (Promocells), hesperetin (100–300 nM, 15 min) caused significant increases in the level of ERK1/2 phosphorylation, but did not increase CREB phosphorylation. Administration of hesperetin for 18 h did not alter gene expression driven by the cyclic AMP response element (CRE), assessed using a luciferase reporter system, but 300 nM hesperetin partially reversed staurosporine-induced cell death in primary neurones. Our data show that hesperetin is a neuroprotective compound at concentrations where antioxidant effects are unlikely to predominate. The effects of hesperetin are cell-type dependent and, unlike the flavanol (−)epicatechin, neuroprotection in vitro is not associated with enhanced CREB phosphorylation or CRE-mediated gene expression.

Details

Title: Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation
Authors/Creators: S. Rainey-Smith (Author/Creator)
L-W Schroetke (Author/Creator) - Wolfson Centre for Age-Related Diseases
P. Bahia (Author/Creator) - Wolfson Centre for Age-Related Diseases
A. Fahmi (Author/Creator) - Wolfson Centre for Age-Related Diseases
R. Skilton (Author/Creator) - Wolfson Centre for Age-Related Diseases
J.P.E. Spencer (Author/Creator) - Wolfson Centre for Age-Related Diseases
C. Rice-Evans (Author/Creator) - Wolfson Centre for Age-Related Diseases
M. Rattray (Author/Creator) - University of Reading
R.J. Williams (Author/Creator) - Wolfson Centre for Age-Related Diseases
Publication Details: Neuroscience Letters, Vol.438(1), pp.29-33
Publisher: Elsevier
Identifiers: 991005543600807891
Copyright: © 2008 Elsevier Ireland Ltd.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.16 Phytochemicals; 3.16.28 Antioxidant Activity
Web Of Science research areas: Neurosciences
ESI research areas: Neuroscience & Behavior