Journal article
Neutrophil function in duchenne muscular dystrophy
Journal of the Neurological Sciences, Vol.73(1), pp.73-77
1986
Abstract
Spontaneous migration, chemotactic and bactericidal activity and nitrobluetetrazolium (NBT) reduction by neutrophils from patients with Duchenne muscular dystrophy were evaluated using quantitative techniques. Significant reductions in spontaneous migration and chemotaxis were found in the DMD group when compared with a control group of subjects. No significant differences were found in bactericidal activity or NBT reduction. The findings suggest that there is a defect in the contractile system or cell membrane function of neutrophils in DMD and that the genetic defect is expressed in leucocytes as well as other tissues.
Details
- Title
- Neutrophil function in duchenne muscular dystrophy
- Authors/Creators
- U. Karagol (Author/Creator) - Muscular Dystrophy Research Laboratories, General Hospital, Newcastle upon Tyne U.K.D. Gardner-Medwin (Author/Creator) - Muscular Dystrophy Research Laboratories, General Hospital, Newcastle upon Tyne U.K.F.L. Mastaglia (Author/Creator) - Muscular Dystrophy Research Laboratories, General Hospital, Newcastle upon Tyne U.K.
- Publication Details
- Journal of the Neurological Sciences, Vol.73(1), pp.73-77
- Publisher
- Elsevier BV
- Identifiers
- 991005546037307891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.127 Molecular & Cell Biology - Pharmacology
- 1.127.938 NADPH Oxidase
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior