Journal article
New genetic predictors for abacavir tolerance in HLA-B*57:01 positive individuals
Human Immunology, Vol.81(6), pp.300-304
2020
Abstract
Abacavir hypersensitivity syndrome (ABC HSS) is strongly associated with carriage of human leukocyte antigen (HLA)-B*57:01, which has a 100% negative predictive value for the development of ABC HSS. However, 45% of individuals who carry HLA-B*57:01 can tolerate ABC. We investigated immune and non-immune related genes in ABC HSS (n = 95) and ABC tolerant (n = 43) HLA-B*57:01 + patients to determine other factors required for the development of ABC HSS. Assignment of phenotype showed that ABC HSS subjects were significantly less likely than tolerants to carry only ERAP1 hypoactive trimming allotypes (p = 0.02). An altered self-peptide repertoire model by which abacavir activates T cells is in keeping with observation that endoplasmic reticulum aminopeptidase 1 (ERAP1) allotypes that favour efficient peptide trimming are more common in ABC HSS patients compared to patients who tolerate ABC. Independently, non-specific immune activation via soluble cluster of differentiation antigen 14 (sCD14) may also influence susceptibility to ABC HSS.
Details
- Title
- New genetic predictors for abacavir tolerance in HLA-B*57:01 positive individuals
- Authors/Creators
- R. Pavlos (Author/Creator) - The Kids Research Institute AustraliaP. Deshpande (Author/Creator) - The University of Western AustraliaA. Chopra (Author/Creator) - Murdoch UniversityS. Leary (Author/Creator) - Murdoch UniversityK. Strautins (Author/Creator) - Murdoch UniversityD. Nolan (Author/Creator) - Institute for Immunology and Infectious Diseases, Murdoch University, Western Australia, Australia; Department of Clinical Immunology, Royal Perth Hospital, Western Australia, Australia.D. Thorborn (Author/Creator) - Celgene Corporation, NJ, USAM. Shaefer (Author/Creator) - Research Triangle Park FoundationA. Rauch (Author/Creator) - University Hospital of BernD. Dunn (Author/Creator) - Murdoch UniversityJ. Montaner (Author/Creator)A. Rachlis (Author/Creator) - Sunnybrook Health Science CentreC.M. Almeida (Author/Creator)L. Choo (Author/Creator) - Murdoch UniversityI. James (Author/Creator) - Murdoch UniversityA.J. Redwood (Author/Creator) - The University of Western AustraliaY. Li (Author/Creator) - The University of Western AustraliaS. Gaudieri (Author/Creator) - The University of Western AustraliaS.A. Mallal (Author/Creator) - Murdoch UniversityE.J. Phillips (Author/Creator) - Murdoch University
- Publication Details
- Human Immunology, Vol.81(6), pp.300-304
- Publisher
- Elsevier BV
- Identifiers
- 991005543660207891
- Copyright
- © 2020 American Society for Histocompatibility and Immunogenetics.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.265 Dermatology - Skin Allergies
- 1.265.1140 Drug Hypersensitivity
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology