Journal article
New insights into the regulation of erythroid cells
IUBMB Life, Vol.56(4), pp.177-184
2004
Abstract
The regulation of erythroid cells is complex and occurs at multiple levels. Erythroid precursors, once committed to this lineage, develop in association with specific macrophages within erythroblastic islands. While erythropoietin (Epo) is the principal regulator of erythroid progenitors, other cytokines and nuclear hormones also play an important role in the maturation of these cells. Signalling from the Epo-receptor activates several pathways, including the JAK/STAT, ras/raf/MAP kinase and PI3 kinase/Akt cascades to promote cell survival, proliferation and differentiation. Transcription factors such as GATA-1, EKLF and NF-E2 are crucial for progression along the erythroid maturation pathway; these, and a myriad of other transcription factors, must be expressed at the correct developmental stage for normal red blood cells to be formed.
Details
- Title
- New insights into the regulation of erythroid cells
- Authors/Creators
- E. Ingley (Author/Creator) - The University of Western AustraliaP.A. Tilbrook (Author/Creator) - The University of Western AustraliaS.P. Klinken (Author/Creator) - The University of Western Australia
- Publication Details
- IUBMB Life, Vol.56(4), pp.177-184
- Publisher
- Wiley
- Identifiers
- 991005541400707891
- Copyright
- © 2004 International Union of Biochemistry and Molecular Biology
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.184 Physiology & Metals
- 1.184.1030 Erythropoietin Therapy
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- ESI research areas
- Biology & Biochemistry